Applying for our second CTSA, Tufts Clinical and Translational Science Institute (CTSl) remains avidly committed to involving the full spectrum of clinical ahd translational research (CTR) to meet th(c) promise of biomedical science, not only bench to bedside (T1"""""""") translation, crucial to having health impact, translation into effective clinical practice (""""""""T2""""""""), care delivery and public health (""""""""T3""""""""), and health policy ('T4""""""""). In 2008 we started Tufts CTSI building on prior CTR resources, services, and educational programs, we purposely selected partners that would leverage and complement each other's special assets. Our 38 strategically- chosen partners include 12 Tufts University schools/research centers, ten Tufts hospitals, three academic institutions (Brandeis University, Northeastern University, RAND Corporation), eight community-based organizations, and five industry partners, an outstanding and synergistic resources, opportunities, and education across the T1-T4 spectrum. Described in our application's four sections are four aims that build on this platform:
AIM 1 : Strengthen Tufls CTSI overall by;1) organizing and leading its partners in their commitment to this shared home for CTR;2) expanding efficient access for ail partners to a full spectrum of high-quality resources in a way that promotes collaborative CTR across disciplines and institutions;3) advancing the field of CTR through local and national leadership and development of novel methods;4) providing innovative and targeted education and training across the T1-4 spectrum. (Section I) AIM 2: Operationalize and implement the CTR home and its infra- stnjcture, sen/ices and programs, including Its central office personnel, administrative and financial management systems, committees, and other necessary structures. (Section II) AIM 3: Sustain and grow innovative resources, services, and policies that support and promote collaborative, cross-disciplinary, full-spectrum translational research. (Section III) AIM 4:Develop and broaden the CTR workforce through education and training across the T1-T4 spectrum, with a specific focus on addressing translational gaps between bench to bedside and from bedside to widespread impact on health. (Section IV)

Public Health Relevance

(See Instructions): Tufts Clinical and Translational Science Institute uses the entire spectrum of clinical and translational research (CTR) to help meet the promise and the public's needs of biomedical science.This includes bench to bedside (""""""""Tl"""""""") translation and crucially for having health impact, translation into effective clinical practice (""""""""T2""""""""), care delivery and public health (""""""""TS""""""""), and health policy ('74"""""""").

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Wilde, David B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Craig, Alexa K; Gerwin, Roslyn; Bainter, Janelle et al. (2018) Exploring Parent Experience of Communication About Therapeutic Hypothermia in the Neonatal Intensive Care Unit. Adv Neonatal Care 18:136-143
May, Teresa L; Riker, Richard R; Seder, David B (2018) Complex Legacy of the Target Temperature Management Trial. Crit Care Med 46:1864-1865
Skeer, Margie R; Ladin, Keren; Wilkins, Lindsay E et al. (2018) 'Hep C's like the common cold': understanding barriers along the HCV care continuum among young people who inject drugs. Drug Alcohol Depend 190:246-254
Riley, Hayden; Headley, Samuel; Lindenauer, Peter K et al. (2018) Patient Perception of How Smoking Status Influences Cardiac Rehabilitation Attendance After an Acute Cardiac Hospitalization. J Cardiopulm Rehabil Prev :
Ladin, Keren; Buttafarro, Katie; Hahn, Emily et al. (2018) ""End-of-Life Care? I'm not Going to Worry About That Yet."" Health Literacy Gaps and End-of-Life Planning Among Elderly Dialysis Patients. Gerontologist 58:290-299
Ladin, Keren; Pandya, Renuka; Kannam, Allison et al. (2018) Discussing Conservative Management With Older Patients With CKD: An Interview Study of Nephrologists. Am J Kidney Dis 71:627-635
Ladin, Keren; Daniels, Alexis; Osani, Mikala et al. (2018) Is social support associated with post-transplant medication adherence and outcomes? A systematic review and meta-analysis. Transplant Rev (Orlando) 32:16-28
May, Teresa L; Riker, Richard R; Fraser, Gilles L et al. (2018) Variation in Sedation and Neuromuscular Blockade Regimens on Outcome After Cardiac Arrest. Crit Care Med 46:e975-e980
Riley, Hayden; Headley, Samuel; Winter, Christa et al. (2018) Effect of Smoking Status on Exercise Perception and Intentions for Cardiac Rehabilitation Enrollment Among Patients Hospitalized With an Acute Cardiac Condition. J Cardiopulm Rehabil Prev 38:286-290
Ladin, Keren; Lin, Naomi; Hahn, Emily et al. (2017) Engagement in decision-making and patient satisfaction: a qualitative study of older patients' perceptions of dialysis initiation and modality decisions. Nephrol Dial Transplant 32:1394-1401

Showing the most recent 10 out of 26 publications