The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and clinical research for not only the Scripps institutions, consisting of The Scripps Research Institute and Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolia Mesa throughout the United States.The Scripps program combines the largest independent biomedical institute in the country with the dominant health care system in San Diego, along with an extensive partnership with the San Diego Supercomputer Center, one of the 4 national resource centers of its kind. Our areas of innovative infrastructure are informatics, genomics, and wireless medicine. Each area has a remarkably transformative potential for the future of medicine and improving the health of the public. Major advances in genomics and wireless technologies have created data torrents that were previously unimaginable, but with advanced analytical capabilities there is a remarkable opportunity to use such data to individualize medicine, defining each unique human being at multiple levels - biological, physiological, and anatomical. By individualizing medicine, there is a scientific foundation for more effective treatments, avoidance of major side effects, a far more precise means of rendering health care, and lowering of costs. Each individual's data and information can be captured with such new tools as wireless biosensors or sequencing of the entire genome. STSI has particular expertise in these tools, which includes not only gathering the data but also superior analytical capabilites. This sets up an innovative infrastructure to provide disease-agnostic resources and services for a highly productive research network - one that has dismantled the silos that previously existed of basic scientists and clinicians. Furthermore, these resources support the training and career development of the leaders of medicine for the future.

Public Health Relevance

Medicine as practiced today consists of mass screening and the use of the same medications for all patients with a particular diagnosis. Our newfound ability to define the medical essence of each individual paves the way for a more efficient, safer, and less expensive form of healthcare in the future. By bringing together an exceptionally talented and productive research community, STSI will catapult this new form of medicine.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR001112-02
Application #
8743355
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Talbot, Bernard
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$715,710
Indirect Cost
$50,793
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Modena, B D; Milam, R; Harrison, F et al. (2016) Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. Am J Transplant :
Kisiel, John B; Konijeti, Gauree G; Piscitello, Andrew J et al. (2016) Stool DNA Analysis is Cost-Effective for Colorectal Cancer Surveillance in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol 14:1778-1787.e8
Jaiswal, Stuti J; Malhotra, Atul; Owens, Robert L (2016) Sleep and critical illness: bridging the two pillars at the ATS 2016. J Thorac Dis 8:S536-8
Konijeti, Gauree Gupta; Arora, Pankaj; Boylan, Matthew R et al. (2016) Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial. J Clin Endocrinol Metab 101:533-8
Nhu, Quan M; Knowles, Harry; Pockros, Paul J et al. (2016) Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma. World J Respirol 6:69-75
Steinhubl, Steven R; Muse, Evan D; Topol, Eric J (2015) The emerging field of mobile health. Sci Transl Med 7:283rv3
Steinhubl, Steven R; Wineinger, Nathan E; Patel, Sheila et al. (2015) Cardiovascular and nervous system changes during meditation. Front Hum Neurosci 9:145
Muse, Evan D; Feldman, David I; Blaha, Michael J et al. (2015) The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 239:101-8
Bloss, Cinnamon S; Zeeland, Ashley A Scott-Van; Topol, Sarah E et al. (2015) A genome sequencing program for novel undiagnosed diseases. Genet Med 17:995-1001
Philis-Tsimikas, Athena; Gallo, Linda C (2014) Implementing community-based diabetes programs: the scripps whittier diabetes institute experience. Curr Diab Rep 14:462

Showing the most recent 10 out of 11 publications