The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and clinical research for not only the Scripps institutions, consisting of The Scripps Research Institute and Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolia Mesa throughout the United States.The Scripps program combines the largest independent biomedical institute in the country with the dominant health care system in San Diego, along with an extensive partnership with the San Diego Supercomputer Center, one of the 4 national resource centers of its kind. Our areas of innovative infrastructure are informatics, genomics, and wireless medicine. Each area has a remarkably transformative potential for the future of medicine and improving the health of the public. Major advances in genomics and wireless technologies have created data torrents that were previously unimaginable, but with advanced analytical capabilities there is a remarkable opportunity to use such data to individualize medicine, defining each unique human being at multiple levels - biological, physiological, and anatomical. By individualizing medicine, there is a scientific foundation for more effective treatments, avoidance of major side effects, a far more precise means of rendering health care, and lowering of costs. Each individual's data and information can be captured with such new tools as wireless biosensors or sequencing of the entire genome. STSI has particular expertise in these tools, which includes not only gathering the data but also superior analytical capabilites. This sets up an innovative infrastructure to provide disease-agnostic resources and services for a highly productive research network - one that has dismantled the silos that previously existed of basic scientists and clinicians. Furthermore, these resources support the training and career development of the leaders of medicine for the future.

Public Health Relevance

Medicine as practiced today consists of mass screening and the use of the same medications for all patients with a particular diagnosis. Our newfound ability to define the medical essence of each individual paves the way for a more efficient, safer, and less expensive form of healthcare in the future. By bringing together an exceptionally talented and productive research community, STSI will catapult this new form of medicine.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
1KL2TR001112-01
Application #
8721043
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Talbot, Bernard
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2013-09-26
Budget End
2014-04-30
Support Year
1
Fiscal Year
2013
Total Cost
$503,941
Indirect Cost
$35,817
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Muse, Evan D; Yu, Shan; Edillor, Chantle R et al. (2018) Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc Natl Acad Sci U S A 115:E4680-E4689
Muse, Evan D; Wineinger, Nathan E; Spencer, Emily G et al. (2018) Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study. PLoS Med 15:e1002525
Sharma, Siddhartha; Gioia, Louis; Abe, Brian et al. (2018) Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges. Mol Immunol 103:191-199
Chandradas, Sajiv; Khalili, Hamed; Ananthakrishnan, Ashwin et al. (2018) Does Obesity Influence the Risk of Clostridium difficile Infection Among Patients with Ulcerative Colitis? Dig Dis Sci 63:2445-2450
Jaiswal, Stuti J; McCarthy, Thomas J; Wineinger, Nathan E et al. (2018) Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial. Am J Med 131:1110-1117.e4
Nhu, Q M; Pockros, P J (2018) Editorial: chronic hepatitis B combination therapy-emerging success as proof-of-concept for future hepatitis B eradication? Aliment Pharmacol Ther 47:1560-1561
Jahromi, Behnam Moein; Nhu, Quan M; Moawad, Fouad J (2018) Metastatic Cervical Cancer Causing Esophageal Compression and Dysphagia. Clin Gastroenterol Hepatol :
Modena, Brian D; Bellahsen, Otmane; Nikzad, Nima et al. (2018) Advanced and Accurate Mobile Health Tracking Devices Record New Cardiac Vital Signs. Hypertension 72:503-510
Modena, Brian D; Bleecker, Eugene R; Busse, William W et al. (2017) Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. Am J Respir Crit Care Med 195:1449-1463
Muse, Evan D; Barrett, Paddy M; Steinhubl, Steven R et al. (2017) Towards a smart medical home. Lancet 389:358

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