This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goals of this project are investigation of appetite suppression produced by consumption of ethyl oleate (EO), a fatty acid ethyl ester, by human subjects and comparison of brain activation produced by EO with that resulting from consumption of other macronutrients - carbohydrates, proteins, and triglycerides. However, the pilot studies proposed here will focus on EO in comparison to vehicle control. Our previous studies in rats have shown that EO is more potent in suppressing subsequent food intake than any of these other substances and will produce weight loss with repeat dosing. The results suggest the potential usefulness of EO for weight management and also raise basic questions about the physiological basis for EO's high satiating potency. To address these issues, two studies will use functional magnetic resonance imaging (fMRI) to examine brain areas known to be involved in regulation of food intake and body weight, the medial and lateral hypothalamus, amygdala, and orbitofrontal cortex. Participants will consume a beverage containing EO or a non-caloric control beverage on separate days and provide self-report measures on such variables as hunger and satiety. In one study brain activity will be imaged before and after consumption of the beverage within the magnet. The time course of resulting changes in activation will be analyzed using a new procedure, temporal clustering analysis. A second fMRI study will investigate the effect of EO on brain activation evoked by pictures of food and non-food objects.
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