Keywords: Conditions Affecting Unborn Children;Perinatal Assessments;Infertility;Prevention;Estrogens;Androgens;Genetics;Reproductive Assessment by Continuous Breeding (RACB);multigenerational reproductive evaluation;Computer Assisted Semen Analyis (CASA);sperm count and motility;vaginal cytology;estrous cyclicity;endocrine disrupting chemicals;antiretroviral agents;infertility;pregnancy loss;birth defects;dosing pre-weaning mouse pups;rats;mice. A contract was awarded in 2008 which will allow testing of 6-8 environmental agents of interest to the National Toxicology Program, and regulatory agencies such as the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), for their ability to impair fertility (conception or pregnancy) and/or fecundity (number of progeny, viable healthy offpring). A Phase 1 study was initiated using a know reproductive/developmental toxicant to evaluate the capability of the contract laboratory to successfully perform all aspects of the multi-generational study design. The study has progressed through production of first- and second-generation offspring, and detailed evaluation of those offspring and analysis of the data is in process.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
N01ES75564-11-0-1
Application #
8672531
Study Section
Project Start
2007-05-01
Project End
2013-06-15
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$2,500,000
Indirect Cost
Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709