Core B will serve as the Optical Imaging and Small Animal Imaging core of the Program Project. Dr. James Lechleiter is the core leader and will be responsible for the following: 1) providing optical microscope instrumentation for all of the principle investigators of the program project, in particular access to confocal, multiphoton and whole animal imaging, 2) coordinating efforts of each project to incorporate novel techniques such as in vivo optical imaging, Micro-SPECT, Micro-PET and Micro-CT to monitor metabolism, DNA proliferation, and apoptosis with anatomic imaging correlation during aging, 3) providing consultation and education regarding the theory and application of optical imaging to the participants of the program project to insure the quality of research conducted by the projects and cores, 4) providing computer hardware and software for analysis of digital images and production of publication quality prints. Core B will take advantage of the instrumentation already in operation in the Core Optical Imaging Facility and the Dept. of Radiology at UTHSCSA. By coordinating efforts through recognized experts in each organization, Program Project members will have access to state-of-the-art instrumentation for optical and small animal imaging thus enabling them to implement novel methodologies for the study of aging in living cells, tissues and whole animal models.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG019316-10
Application #
8222865
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
2013-01-31
Budget Start
2011-02-01
Budget End
2013-01-31
Support Year
10
Fiscal Year
2011
Total Cost
$216,166
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Wu, Junjie; Sun, Yun; Block, Travis J et al. (2016) Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics. Stem Cell Res Ther 7:176
Doiron, Bruno; Hu, Wenchao; DeFronzo, Ralph A (2016) Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice. Curr Pharm Biotechnol 17:376-88
Solano Fonseca, Rene; Mahesula, Swetha; Apple, Deana M et al. (2016) Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis. Stem Cells Dev 25:542-55
Callaway, Danielle A; Riquelme, Manuel A; Sharma, Ramaswamy et al. (2015) Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone 76:40-8
Lee, Hak Joo; Feliers, Denis; Mariappan, Meenalakshmi M et al. (2015) Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes. J Biol Chem 290:12014-26
Talley Watts, Lora; Zheng, Wei; Garling, R Justin et al. (2015) Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke. J Vis Exp :e52794
Choveau, Frank S; Zhang, Jie; Bierbower, Sonya M et al. (2015) The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking. PLoS One 10:e0145367
Souto Padron de Figueiredo, Alvaro; Salmon, Adam B; Bruno, Francesca et al. (2015) Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet. J Biol Chem 290:13427-39
Talley Watts, Lora; Long, Justin Alexander; Manga, Venkata Hemanth et al. (2015) Normobaric oxygen worsens outcome after a moderate traumatic brain injury. J Cereb Blood Flow Metab 35:1137-44
Segovia, Jesus A; Tsai, Su-Yu; Chang, Te-Hung et al. (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol Cell Biol 35:582-97

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