Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038508-02
Application #
2075563
Study Section
Special Emphasis Panel (SRC (87))
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Lee, Ni; Geraghty, Daniel E (2003) HLA-F surface expression on B cell and monocyte cell lines is partially independent from tapasin and completely independent from TAP. J Immunol 171:5264-71
Ishitani, Akiko; Sageshima, Noriko; Lee, Ni et al. (2003) Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition. J Immunol 171:1376-84
Strong, Roland K; Holmes, Margaret A; Li, Pingwei et al. (2003) HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities. J Biol Chem 278:5082-90
Navarro, F; Llano, M; Bellon, T et al. (1999) The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol 29:277-83
Lee, N; Goodlett, D R; Ishitani, A et al. (1998) HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J Immunol 160:4951-60
Llano, M; Lee, N; Navarro, F et al. (1998) HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer. Eur J Immunol 28:2854-63
Lee, N; Llano, M; Carretero, M et al. (1998) HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci U S A 95:5199-204
Janer, M; Guillaudeux, T; Geraghty, D et al. (1996) The telomeric and centromeric ends of HLA class I: MCD maps of YAC derived cosmids and sequence analysis of 740 kb of genomic DNA. DNA Seq 7:33-8
Grandea 3rd, A G; Androlewicz, M J; Athwal, R S et al. (1995) Dependence of peptide binding by MHC class I molecules on their interaction with TAP. Science 270:105-8
Lee, N; Malacko, A R; Ishitani, A et al. (1995) The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity 3:591-600