Abstract

To develop improved therapeutic approaches whereby T-cell depleted, HLA haplotype disparate marrow transplants can be used to consistently achieve engraftment and full recovery of immune function with graft vs. host disease in patients with: a) variants of SCID exhibiting graft resistance; b) Other diseases associated with a lethal combined immunodeficiency, and c) Wiskott-Aldrich syndrome, who lack an HLA-identical donor

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI032918-11
Application #
2067841
Study Section
Special Emphasis Panel (SRC (O2))
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1995-08-31
Support Year
11
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Gillio, A P; Boulad, F; Small, T N et al. (1997) Comparison of long-term outcome of children with severe aplastic anemia treated with immunosuppression versus bone marrow transplantation. Biol Blood Marrow Transplant 3:18-24
Dennig, D; Yan, Y; Ferguson, K et al. (1996) A novel HLA class II-independent TCR-mediated T cell activation mechanism is distinguished by the V beta specificity of the proliferating oligoclones and their capacity to generate interleukin-2. Cell Immunol 171:200-10
Wagner, J E; Kernan, N A; Steinbuch, M et al. (1995) Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346:214-9
Pepper, A E; Buckley, R H; Small, T N et al. (1995) Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am J Hum Genet 57:564-71
Boulad, F; Gillio, A; Small, T N et al. (1994) Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant. Bone Marrow Transplant 13:661-3
Shieh, J H; Peterson, R H; Moore, M A (1994) Bacterial endotoxin regulation of cytokine receptors on murine bone marrow cells: in vivo and in vitro study. J Immunol 152:859-66
Shieh, J H; Peterson, R H; Moore, M A (1993) Cytokines and dexamethasone modulation of IL-1 receptors on human neutrophils in vitro. J Immunol 150:3515-24
Gillio, A P; Faulkner, L B; Alter, B P et al. (1993) Treatment of Diamond-Blackfan anemia with recombinant human interleukin-3. Blood 82:744-51