To develop improved therapeutic approaches whereby T-cell depleted, HLA haplotype disparate marrow transplants can be used to consistently achieve engraftment and full recovery of immune function with graft vs. host disease in patients with: a) variants of SCID exhibiting graft resistance; b) Other diseases associated with a lethal combined immunodeficiency, and c) Wiskott-Aldrich syndrome, who lack an HLA-identical donor

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
9P01AI032918-09
Application #
3092135
Study Section
Special Emphasis Panel (SRC (O2))
Project Start
1991-09-30
Project End
1994-08-31
Budget Start
1991-09-30
Budget End
1992-08-31
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
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Dennig, D; Yan, Y; Ferguson, K et al. (1996) A novel HLA class II-independent TCR-mediated T cell activation mechanism is distinguished by the V beta specificity of the proliferating oligoclones and their capacity to generate interleukin-2. Cell Immunol 171:200-10
Wagner, J E; Kernan, N A; Steinbuch, M et al. (1995) Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346:214-9
Pepper, A E; Buckley, R H; Small, T N et al. (1995) Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am J Hum Genet 57:564-71
Boulad, F; Gillio, A; Small, T N et al. (1994) Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant. Bone Marrow Transplant 13:661-3
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