The overarching main objective of this Program Project is to understand the mechanisms through which autoantigen/autoantibody complexes contribute to the initiation and/or maintainence of systemic lupus erythematosus. The various projects in the Program will rely, in part, on a number of antigens, antibodies and viral vectors to carry out the proposed specific aims. The successful completion of these aims has been and will continue to be enhanced by the availability of a set of highly defined, quality controlled reagents that will be produced by this Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR050256-10
Application #
8378442
Study Section
Special Emphasis Panel (ZAR1-EHB-D)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$2
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
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Moody, Krishna L; Uccellini, Melissa B; Avalos, Ana M et al. (2016) Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. Methods Mol Biol 1390:249-72
Pawaria, Sudesh; Moody, Krishna L; Busto, Patricia et al. (2015) An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol 33:S70-3

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