Core A will coordinate, align, and connect the elements of the PPG team, including scientific and administrative functions, meetings, communications, project and core interactions, and financial management. Core A assumes administrative and financial burdens and promotes an informed and collegial intellectual environment for the researchers. The core fulfills essential oversight and management responsibilities and maximizes the efficient utilization of resources. The Core A Leader, also PPG PI, Dr. Randall W. Burt, is responsible for major scientific and administrative policy and direction decisions, and for resolving issues that affect more than one project or core. Responsible investigators and external and internal advisory boards also provide input. Core A is staffed by personnel knowledgeable in scientific and technical matters, regulatory issues, and financial affairs. Core A staff includes a research scientist/genetic counselor, an experienced financial analyst, a grants administrator, and clerical staff with proficiency in office management and a thorough understanding of NIH processes and University policies. These core personnel have functioned together well for the past cycle. Scientific and Administrative Activities. Core A will maintain an active leadership presence in the PPG to: form and execute scientific, administrative, and operational plans and policies;facilitate and encourage effective communication among all PPG members, as well as with External and Internal Scientific Advisory Boards;guide and coordinate PPG research directions;act as an enabling interface between PPG researchers and institutional resources;review progress and develop new opportunities for collaborations; and compile a record of program discoveries, publications, and presentations. Financial Resources Management. Core A will responsibly manage all financial aspects of the PPG, including disbursement of funds, review of expenditures, preparation of regular reports, and annual review of resource allocation among PPG investigators. Oversight and Compliance. Core A will establish methods of effective oversight, utilize the expertise of advisors, ensure compliance with NIH guidelines regarding human and vertebrate animal research, ensure that PPG research abides by appropriate regulatory approvals, and ensure that data sharing is conducted in a manner consistent with regulations and ethical standards, especially in regards to patient confidentiality.
The goal of the PPG is to create a synergistic team of similarly committed researchers who mesh the skills, intellect, and resources of multiple laboratories and clinical facilities in an optimal research environment. Administrative and financial coordination of these resources and activities is a key element required for success of the PPG. This function is carried out by the Administrative Core Director and staff members.
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|Gan, Meng; Boothe, Dustin; Neklason, Deborah W et al. (2017) Outcomes and complications of radiation therapy in patients with familial adenomatous polyposis. J Gastrointest Oncol 8:643-649|
|Bice, Benjamin D; Stephens, Megan R; Georges, Stephanie J et al. (2017) Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumor Model. Cell Rep 19:760-773|
|Kanth, Priyanka; Bronner, Mary P; Boucher, Kenneth M et al. (2016) Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype. Cancer Prev Res (Phila) 9:456-65|
|Burt, Randall W (2016) Screening and Survival in Familial Adenomatous Polyposis. J Clin Gastroenterol 50:3-4|
|Samadder, N Jewel; Smith, Ken Robert; Hanson, Heidi et al. (2016) Familial Risk in Patients With Carcinoma of Unknown Primary. JAMA Oncol 2:340-6|
|Neklason, Deborah W; VanDerslice, James; Curtin, Karen et al. (2016) Evidence for a heritable contribution to neuroendocrine tumors of the small intestine. Endocr Relat Cancer 23:93-100|
|Li, Jun; Woods, Susan L; Healey, Sue et al. (2016) Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. Am J Hum Genet 98:830-842|
|Samadder, N Jewel; Curtin, Karen; Pappas, Lisa et al. (2016) Risk of Incident Colorectal Cancer and Death After Colonoscopy: A Population-based Study in Utah. Clin Gastroenterol Hepatol 14:279-86.e1-2|
|Samadder, N Jewel; Neklason, Deborah W; Boucher, Kenneth M et al. (2016) Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. JAMA 315:1266-75|
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