pRnvinpn Core C has both research and service goals, with the overall theme of developing new and useful imaging and dosimetry approaches to help optimize PDT in preclinical models and clinical studies. The systems used by each project vary considerably,yet the file systems, data analysis, planning and dosimetry concepts can be centralized and inter-project communication in this area can significantly enhance the quality of research. The core is subdivided into four distinct aims, including (!) Structural and functional imaging and dosimetry;(ii) Photophysical imaging/monitoring in vivo;(iii) Molecular imaging in vivo;and (iv)Technology translation.
These aims all work with the projects to ensure that developments from one project may assist in another, and that methods, doses, image files, and developed softwaregets used to the highest potential. There are specific areas in structural dosimetry which will be developed including optical imaging translation, clinical dosimetry, mesh creation and light modeling tools, and visualization software. The core will assist Projects 1 and 2 in establishing functioning dosimetry system for all clinical trials, complete with instrumentation to measure the light and PS, as well as treatment planning software which has the capabilities to adapt the light doses in real time. The photophysical dosimetry will involve development of a specialized high resolution fluorescence imaging system for skin cancer treatment mapping. The variance of PS concentration will be studied in both skin and pancreatic cancer models, as well as installation and testing of singletoxygen dosimetry in collaboration with PSI. The recent developments in molecular imaging will be extended into imaging in vivo, and be used to quantify the expression EGFR, VEGF levels, and expression of other key proteins in vivo. Integrated optical tomography with MRI, US, CT will be used to study these with high image resolution.
The final aim tackles the complex issue of technology transfer, and when to spend time on patenting and shareware distribution of technology. We have partners in several companies, and these will be leveraged to help guide our next steps, as well as working through the technology transfer offices of each institution, and the CIMIT center at MGH to fulfill the NIH Roadmap goals of private public partnerships. The core will administer and update a share ware site for distribution of software tools and dosimetry designs, for systems, which do not have immediate commercial potential, yet would benefit the field of PDT in general by distribution to other academic centers. The core is centered at Dartmouth and MGH, as these sites have been the locus of technology developments in the past funding period, yet the key personnel and collaborators at each site have planned bi-annual meetings and more often weekly meetings planned during clinical trials. Enhanced file transfer and customized software tools will improve the interactions planned and make this core significantly improve the quality of research at each of the project sites. The potential benefits to public health that this Core provides is in the form of new dosimetry and imaging tools for better treatment outcomes and initiating commercialization of research in the Program in partnership with industry.
|Pereira, S P; Goodchild, G; Webster, G J M (2018) The endoscopist and malignant and non-malignant biliary obstruction. Biochim Biophys Acta Mol Basis Dis 1864:1478-1483|
|Broekgaarden, Mans; Rizvi, Imran; Bulin, Anne-Laure et al. (2018) Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget 9:13009-13022|
|Huang, Huang-Chiao; Rizvi, Imran; Liu, Joyce et al. (2018) Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery. Cancer Res 78:558-571|
|Huang, Huang-Chiao; Pigula, Michael; Fang, Yanyan et al. (2018) Immobilization of Photo-Immunoconjugates on Nanoparticles Leads to Enhanced Light-Activated Biological Effects. Small :e1800236|
|Wang, Hexuan; Mislati, Reem; Ahmed, Rifat et al. (2018) Elastography can map the local inverse relationship between shear modulus and drug delivery within the pancreatic ductal adenocarcinoma microenvironment. Clin Cancer Res :|
|Obaid, Girgis; Jin, Wendong; Bano, Shazia et al. (2018) Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells. Photochem Photobiol :|
|Marra, Kayla; LaRochelle, Ethan P; Chapman, M Shane et al. (2018) Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo. Photochem Photobiol 94:1049-1057|
|Pereira, Stephen P; Jitlal, Mark; Duggan, Marian et al. (2018) PHOTOSTENT-02: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with locally advanced or metastatic biliary tract cancer. ESMO Open 3:e000379|
|Maytin, Edward V; Kaw, Urvashi; Ilyas, Muneeb et al. (2018) Blue light versus red light for photodynamic therapy of basal cell carcinoma in patients with Gorlin syndrome: A bilaterally controlled comparison study. Photodiagnosis Photodyn Ther 22:7-13|
|de Souza, Ana Luiza Ribeiro; LaRochelle, Ethan; Marra, Kayla et al. (2017) Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ. Photodiagnosis Photodyn Ther 20:227-233|
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