Core B: Cohort management and coordination of clinical research activities The overall aim of Core B is to support, the scientific investigations of the individual projects and the POl, while providing our study patients state-of-the-art clinical management of their Barrett's esophagus (BE) at three centers with expertise in the management of these patients to keep them safe from developing advanced incurable esophageal adenocarcinoma. Core B will continue longitudinal biospecimen collection in, and characterization of, an established cohort of patients who have Barrett's esophagus as well as to continue recruitment of new study patients at two additional study sites, to meet the aims of Projects 2 and 3 and the overall goals of the POl.The Seattle Barrett's Esophagus Research Study has a cohort of study patients who have Barrett's esophagus (BE), who represent various stages of progression to esophageal adenocarcinoma (EA), and from whom biopsies have been collected longitudinally and stored in our biorespository since 1989. Addition of two new study sites with standardized research protocols performed and monitored under the auspices of Core B, will allow the POl to retain its longitudinal cohort design while enrolling patients undergoing endoscopic therapy, not performed at our current study site, to meet the Aims of Projects 2 and 3.
Specific Aim 1 : To support the aims of the POl with the addition of two Core B study sites to ensure enrollment and longitudinal follow-up of new study patients with BE undergoing endoscopic therapy to meet the aims of Projects 2 and 3.
Specific Aim 2 : To support the overall POl by continuing longitudinal endoscopic biopsy acquisition over time in the same individual who is part of a wellcharacterized cohort of patients with BE for future validation studies, while maintaining our cohort study design.
Specific Aim 3 : To coordinate study patient recruitment, manage research-related activities and track patient safety, outcomes and protocol compliance at all three study sites to ensure full integration of the new study sites into Core B to meet the aims of the POl.

Public Health Relevance

In Barrett's esophagus, the development of cancer is a dynamic process that evolves slowly over time in some patients, rapidly in others, or in most, remains stable without developing cancer. It is an ideal model to study the genomic evolution associated with the development of cancer over time because we are able to safely and periodically biopsy the same patient's Barrett's esophagus during long-term follow-up.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA091955-11A1
Application #
8668337
Study Section
Special Emphasis Panel (ZCA1-RPRB-B (J1))
Project Start
2002-08-16
Project End
2019-03-31
Budget Start
2014-09-18
Budget End
2015-03-31
Support Year
11
Fiscal Year
2014
Total Cost
$578,205
Indirect Cost
$229,144
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Martinez, Pierre; Timmer, Margriet R; Lau, Chiu T et al. (2016) Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus. Nat Commun 7:12158
Andor, Noemi; Graham, Trevor A; Jansen, Marnix et al. (2016) Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med 22:105-13
Kostadinov, Rumen; Maley, Carlo C; Kuhner, Mary K (2016) Bulk Genotyping of Biopsies Can Create Spurious Evidence for Hetereogeneity in Mutation Content. PLoS Comput Biol 12:e1004413
Reid, Brian J (2016) Surrogate Markers: Lessons from the Next Gen? Cancer Prev Res (Phila) 9:512-7
Kuhner, Mary K; Kostadinov, Rumen; Reid, Brian J (2016) Limitations of the Driver/Passenger Model in Cancer Prevention. Cancer Prev Res (Phila) 9:335-8
Ek, Weronica E; Lagergren, Katarina; Cook, Michael et al. (2016) Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer 138:1146-52
Palles, Claire; Chegwidden, Laura; Li, Xinzhong et al. (2015) Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. Gastroenterology 148:367-78
Nunney, Leonard; Maley, Carlo C; Breen, Matthew et al. (2015) Peto's paradox and the promise of comparative oncology. Philos Trans R Soc Lond B Biol Sci 370:
Li, Xiaohong; Paulson, Thomas G; Galipeau, Patricia C et al. (2015) Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus. Cancer Prev Res (Phila) 8:845-56
Walther, Viola; Hiley, Crispin T; Shibata, Darryl et al. (2015) Can oncology recapitulate paleontology? Lessons from species extinctions. Nat Rev Clin Oncol 12:273-85

Showing the most recent 10 out of 109 publications