Chronic stress for children growing up in poverty may lead to lasting effects on social, behavioral, and cognitive development. The difficulties of living in economic hardship has, indeed, been associated with deficits in cognitive and academic performance. The current study examines the link between poverty and executive functions (cognitive processes that facilitate learning, self-monitoring, and decision making) which are known to undergo rapid developmental change during the first years of life. Early neurological development will be examined as a mediator of this association examined from pregnancy to age 3. In addition to distal risk associated with living in poverty, we will investigate critical experiences within the proximal context (i.e., language exposure, caregiver behavior, child sleep hygiene) that may mediate the effect of this risk on child structural and functional brain development. Participants (n= 230) will be seen during the 28th week of pregnancy, and at 5 visits across the first 3 years of their child's life. Neuroimaging will be conducted at 2 weeks, 15 and 24 months (with an accompanying lab visit at 15 months). We will focus on developing white matter tracts that support cognitive processes of emerging executive functions: anterior cingulum (error monitoring); uncinate (joint attention); arcuate fasciculus (language processing) and individual differences in functional brain development, including resting state networks of salience, attention, executive control, and default-mode. At 6 and 24 months of age, an intensive home visit will include observational and objective measures of caregiver behavior, language exposure (via speech recorders) and sleep hygiene (via actigraphy for 7 days). Child cognitive development will be assessed at each assessment and an executive functioning battery will be administered at 36 months of age. This study will be the first to investigate the influence of poverty on emerging executive functioning at age 3 via effects on child neurological development over the first two years of life. In addition, findings will contribute critical information regarding whether specific measures of proximal experience (language exposure, caregiver behavior, child sleep hygiene) may mediate this risk.

Public Health Relevance

Federal and State governments invest billions of dollars annually in programs that are intended to help ?level the playing field? between children who grow up in poverty relative to their peers who do not. However, these investments typically target the 1-2 years prior to kindergarten, which may be too late according to accumulating evidence that (a) early life experience spanning the prenatal period through the first few years of life has a major and lasting impact on children's cognitive development, academic outcomes and eventual opportunities for success and (b) brain structure and major neural networks that support these abilities resemble adult forms by 2 years of age. The proposed study has the potential to inform early intervention and prevention efforts, which is critically important given the severity of the income achievement gap and the limited public health resources available to address this issue; investments targeting children's early experiences can be more cost effective and impactful for promoting children's learning ability and their eventual opportunity for success.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Psychosocial Development, Risk and Prevention Study Section (PDRP)
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Griffin, James
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University of North Carolina Chapel Hill
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Chapel Hill
United States
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