The Administrative Core A plays an essential role in administering, coordinating, and maintaining the integration and cohesion of this Program as the Project Leaders come from different departments of the Medical School. This Core supports the efforts of the Director, Dr. Chu, and Co-Director, Dr. Cheng, of the Core to oversee and direct the administration and management of this Program and to provide the scientific leadership that ensures the appropriate focus of the Project Leaders and essential scientific interactions. Moreover, this Core will ensure proper coordination of the individual Projects. This Core will provide the appropriate administrative services as well as financial oversight and management to support the Program and the individual Project Leaders. A major function supported by this Core is secretarial assistance to prepare progress reports, continuation reports, and renewals and to organize the Project Leaders monthly meetings. Once the External Advisory Board is constituted, this Core will organize the annual EAB meeting as well as organize the annual retreat. Thus, Core A is a critically important element to allow the Program to function as an efficient and cohesive unit. In addition, Core A will play a key role in ensuring the timely communication and dissemination of results in publications and highlight the progress of the research in various meetings and conferences.

Public Health Relevance

This is an interdepartmental, interdisciplinary multi-investigator grant comprised of 3 Projects designed to investigate the effect of a Chinese herbal medicine as a modulator of cancer chemotherapy. This Core provides administrative support to the P.L, Co-P.l., and Project Leaders to ensure proper coordination of the individual Projects and proper financial oversight.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-GRB-S)
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Yale University
New Haven
United States
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Ryslik, Gregory A; Cheng, Yuwei; Cheung, Kei-Hoi et al. (2014) A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations. BMC Bioinformatics 15:86
Hou, Lin; Chen, Min; Zhang, Clarence K et al. (2014) Guilt by rewiring: gene prioritization through network rewiring in genome wide association studies. Hum Mol Genet 23:2780-90
Ryslik, Gregory A; Cheng, Yuwei; Cheung, Kei-Hoi et al. (2014) A spatial simulation approach to account for protein structure when identifying non-random somatic mutations. BMC Bioinformatics 15:231
Saif, Muhammad Wasif; Li, Jia; Lamb, Lynne et al. (2014) First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancer. Cancer Chemother Pharmacol 73:373-80
Chen, Xiaowei; Slack, Frank J; Zhao, Hongyu (2013) Joint analysis of expression profiles from multiple cancers improves the identification of microRNA-gene interactions. Bioinformatics 29:2137-45
Ryslik, Gregory A; Cheng, Yuwei; Cheung, Kei-Hoi et al. (2013) Utilizing protein structure to identify non-random somatic mutations. BMC Bioinformatics 14:190
Rockwell, Sara; Grove, Tina A; Liu, Yanfeng et al. (2013) Preclinical studies of the Chinese Herbal Medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy. Int J Radiat Biol 89:16-25
Liu, Shwu-Huey; Cheng, Yung-Chi (2012) Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy. J Ethnopharmacol 140:614-23