The Administrative Core A plays an essential role in administering, coordinating, and maintaining the integration and cohesion of this Program as the Project Leaders come from different departments of the Medical School. This Core supports the efforts of the Director, Dr. Chu, and Co-Director, Dr. Cheng, of the Core to oversee and direct the administration and management of this Program and to provide the scientific leadership that ensures the appropriate focus of the Project Leaders and essential scientific interactions. Moreover, this Core will ensure proper coordination of the individual Projects. This Core will provide the appropriate administrative services as well as financial oversight and management to support the Program and the individual Project Leaders. A major function supported by this Core is secretarial assistance to prepare progress reports, continuation reports, and renewals and to organize the Project Leaders monthly meetings. Once the External Advisory Board is constituted, this Core will organize the annual EAB meeting as well as organize the annual retreat. Thus, Core A is a critically important element to allow the Program to function as an efficient and cohesive unit. In addition, Core A will play a key role in ensuring the timely communication and dissemination of results in publications and highlight the progress of the research in various meetings and conferences.

Public Health Relevance

This is an interdepartmental, interdisciplinary multi-investigator grant comprised of 3 Projects designed to investigate the effect of a Chinese herbal medicine as a modulator of cancer chemotherapy. This Core provides administrative support to the P.L, Co-P.l., and Project Leaders to ensure proper coordination of the individual Projects and proper financial oversight.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-GRB-S)
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Yale University
New Haven
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Chen, Mengjie; Ren, Zhao; Zhao, Hongyu et al. (2016) Asymptotically Normal and Efficient Estimation of Covariate-Adjusted Gaussian Graphical Model. J Am Stat Assoc 111:394-406
Li, Cong; Yang, Can; Hather, Greg et al. (2016) Efficient Drug-Pathway Association Analysis via Integrative Penalized Matrix Decomposition. IEEE/ACM Trans Comput Biol Bioinform 13:531-40
Lin, Zhixiang; Li, Mingfeng; Sestan, Nenad et al. (2016) A Markov random field-based approach for joint estimation of differentially expressed genes in mouse transcriptome data. Stat Appl Genet Mol Biol 15:139-50
Zhu, Ruoqing; Zhao, Qing; Zhao, Hongyu et al. (2016) Integrating multidimensional omics data for cancer outcome. Biostatistics 17:605-18
Wang, Tao; Chen, Mengjie; Zhao, Hongyu (2016) Estimating DNA methylation levels by joint modeling of multiple methylation profiles from microarray data. Biometrics 72:354-63
Ryslik, Gregory A; Cheng, Yuwei; Modis, Yorgo et al. (2016) Leveraging protein quaternary structure to identify oncogenic driver mutations. BMC Bioinformatics 17:137
Huang, Xiu; Stern, David F; Zhao, Hongyu (2016) Transcriptional Profiles from Paired Normal Samples Offer Complementary Information on Cancer Patient Survival--Evidence from TCGA Pan-Cancer Data. Sci Rep 6:20567
Hu, Yiming; Zhao, Hongyu (2016) CCor: A whole genome network-based similarity measure between two genes. Biometrics 72:1216-1225
Wang, Ying; Lam, Wing; Chen, Shao-Ru et al. (2016) Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70. Sci Rep 6:32832
Tsou, Lun K; Lara-Tejero, María; RoseFigura, Jordan et al. (2016) Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. J Am Chem Soc 138:2209-18

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