Abstract

We propose to design and test systems for the ablation of pancreatic cancer and other retroperitoneal malignancies using magnetic resonance thermal imaging (MRTI) within a 3 Tesla magnetic resonance. We will design and test ultrasonic delivery systems using ultrasonic applicators directly inserted into tumors (

Public Health Relevance

Pancreatic cancer is currently the fourth leading cause of cancer death in the United States, and treatment is generally of very limited effectiveness. We propose the development and extensive testing of systems for the thermal destruction of pancreatic and other retroperitoneal cancers using guidance available with MR imaging to visualize the heating process during treatment, and evaluate tissue damage following treatment. We will develop systems capable of effective minimally invasive treatment of such malignancies, while sparing normal tissues and improving patient outcomes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA159992-02
Application #
8555395
Study Section
Special Emphasis Panel (ZCA1-GRB-P (M1))
Project Start
2011-09-22
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$174,913
Indirect Cost
$57,452

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Weber, Hans; Hargreaves, Brian A; Daniel, Bruce L (2018) Artifact-reduced imaging of biopsy needles with 2D multispectral imaging. Magn Reson Med 80:655-661
Webb, Taylor D; Leung, Steven A; Rosenberg, Jarrett et al. (2018) Measurements of the Relationship Between CT Hounsfield Units and Acoustic Velocity and How It Changes With Photon Energy and Reconstruction Method. IEEE Trans Ultrason Ferroelectr Freq Control 65:1111-1124
Weber, Hans; Ghanouni, Pejman; Pascal-Tenorio, Aurea et al. (2018) MRI monitoring of focused ultrasound sonications near metallic hardware. Magn Reson Med 80:259-271
Zheng, Yuan; Marx, Michael; Miller, G Wilson et al. (2018) High sensitivity MR acoustic radiation force imaging using transition band balanced steady-state free precession. Magn Reson Med 79:1532-1537
Han, Amy Kyungwon; Bae, Jung Hwa; Gregoriou, Katerina C et al. (2018) MR-Compatible Haptic Display of Membrane Puncture in Robot-Assisted Needle Procedures. IEEE Trans Haptics :
Gibbons, Eric K; Le Roux, Patrick; Pauly, John M et al. (2018) Slice profile effects on nCPMG SS-FSE. Magn Reson Med 79:430-438
Dixit, Neerav; Stang, Pascal P; Pauly, John M et al. (2018) Thermo-Acoustic Ultrasound for Detection of RF-Induced Device Lead Heating in MRI. IEEE Trans Med Imaging 37:536-546
Gibbons, Eric K; Le Roux, Patrick; Vasanawala, Shreyas S et al. (2018) Robust Self-Calibrating nCPMG Acquisition: Application to Body Diffusion-Weighted Imaging. IEEE Trans Med Imaging 37:200-209
Johnson, Ethan M; Vyas, Urvi; Ghanouni, Pejman et al. (2017) Improved cortical bone specificity in UTE MR Imaging. Magn Reson Med 77:684-695
Weber, Hans; Taviani, Valentina; Yoon, Daehyun et al. (2017) MR thermometry near metallic devices using multispectral imaging. Magn Reson Med 77:1162-1169

Showing the most recent 10 out of 64 publications