We propose to design and test systems for the ablation of pancreatic cancer and other retroperitoneal malignancies using magnetic resonance thermal imaging (MRTI) within a 3 Tesla magnetic resonance. We will design and test ultrasonic delivery systems using ultrasonic applicators directly inserted into tumors (

Public Health Relevance

Pancreatic cancer is currently the fourth leading cause of cancer death in the United States, and treatment is generally of very limited effectiveness. We propose the development and extensive testing of systems for the thermal destruction of pancreatic and other retroperitoneal cancers using guidance available with MR imaging to visualize the heating process during treatment, and evaluate tissue damage following treatment. We will develop systems capable of effective minimally invasive treatment of such malignancies, while sparing normal tissues and improving patient outcomes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA159992-02
Application #
8555395
Study Section
Special Emphasis Panel (ZCA1-GRB-P (M1))
Project Start
2011-09-22
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$174,913
Indirect Cost
$57,452
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Bitton, Rachel R; Webb, Taylor D; Pauly, Kim Butts et al. (2016) Improving thermal dose accuracy in magnetic resonance-guided focused ultrasound surgery: Long-term thermometry using a prior baseline as a reference. J Magn Reson Imaging 43:181-9
Adams, Matthew S; Scott, Serena J; Salgaonkar, Vasant A et al. (2016) Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling. Int J Hyperthermia 32:97-111

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