Early stage prostate cancer is very common. However, current methods for diagnosis and treatment miss significant cancers in some men, and over-treat others with therapies that are expensive, lengthy, and have significant risks and morbidity. MRI is emerging as a promising method for revealing clinically significant prostate cancer, raising the provocative possibility of minimally invasive, focal, MR-guided therapy that would be more selective, safer, and quicker than current whole-gland radiotherapy and surgical procedures.
The aims of this project are to develop minimally invasive biopsy and treatment methods for prostate cancer: 1. Design, testing and final fabrication of a new system for real-time, interactive, trans-perineal minimally invasive access to the prostate while the patient is in a 3T MRI scanner, using MRI-compatible robotic technology for passive remote needle manipulation, embedded miniature fiber optics and MR-tracking to sense needle shape and tip position, and integration with real-time MR scanning for automated visualization. 2. Clinical Trial of MRI-guided Trans-perineal biopsy of prostate targets, compared with subsequent TRUS-guided standard systematic 12-core biopsies (the gold standard) in 12 men with abnormal PSA levels. 3. Development and in vivo testing of MRI-compatible needle tip micro-robotics to dramatically increase physician control, including needle tip force sensing and rendering, and photonic needle tip steering. 4. Investigation of 3T methods for guiding and monitoring cryosurgery, including ultra-short TE 3D MR thermal mapping in frozen tissue, and advanced diffusion and MT-weighted images of acute cryo-injury. When complete, these technologies will be poised for future clinical trials assessing the utility of minimally invasive MRI-guided focal cryosurgery for treating early stage prostate cancer
Achieving the aims of this project will provide a simple, powerful, intuitive, elegant method for biopsy and cryoablation of focal prostate targets, using MRI guidance, that is ready for clinical trials. Essential biopsy system components will have been tested in humans. Second generation robotic sensing and control mechanisms, and MRI imaging of tissue freezing effects will have been validated at 3T and tested in vivo.
|Johnson, Ethan M; Vyas, Urvi; Ghanouni, Pejman et al. (2016) Improved cortical bone specificity in UTE MR Imaging. Magn Reson Med :|
|Zhu, Kangrong; Dougherty, Robert F; Wu, Hua et al. (2016) Hybrid-Space SENSE Reconstruction for Simultaneous Multi-Slice MRI. IEEE Trans Med Imaging 35:1824-36|
|Marx, Michael; Butts Pauly, Kim (2016) Improved MRI thermometry with multiple-echo spirals. Magn Reson Med 76:747-56|
|Vyas, Urvi; Ghanouni, Pejman; Halpern, Casey H et al. (2016) Predicting variation in subject thermal response during transcranial magnetic resonance guided focused ultrasound surgery: Comparison in seventeen subject datasets. Med Phys 43:5170|
|Adams, Matthew S; Salgaonkar, Vasant A; Plata-Camargo, Juan et al. (2016) Endoluminal ultrasound applicators for MR-guided thermal ablation of pancreatic tumors: Preliminary design and evaluation in a porcine pancreas model. Med Phys 43:4184|
|Gaur, Pooja; Partanen, Ari; Werner, Beat et al. (2016) Correcting heat-induced chemical shift distortions in proton resonance frequency-shift thermometry. Magn Reson Med 76:172-82|
|Avedian, Raffi S; Bitton, Rachelle; Gold, Garry et al. (2016) Is MR-guided High-intensity Focused Ultrasound a Feasible Treatment Modality for Desmoid Tumors? Clin Orthop Relat Res 474:697-704|
|Ghanouni, Pejman; Dobrotwir, Andrew; Bazzocchi, Alberto et al. (2016) Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol :|
|Bitton, Rachel R; Webb, Taylor D; Pauly, Kim Butts et al. (2016) Improving thermal dose accuracy in magnetic resonance-guided focused ultrasound surgery: Long-term thermometry using a prior baseline as a reference. J Magn Reson Imaging 43:181-9|
|Adams, Matthew S; Scott, Serena J; Salgaonkar, Vasant A et al. (2016) Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling. Int J Hyperthermia 32:97-111|
Showing the most recent 10 out of 48 publications