Schizophrenia is among the most serious and most expensive mental disorders in terms of direct treatment costs, loss of productivity, and expenditures for public assistance, with an estimated annual cost to society of over $62 billion. Almost two thirds of these costs come from patients'diminished capacity for learning, working, self-care, interpersonal relationships, and maintaining general living skills. While skills training interventions have been developed to address skills deficits in this population, patients typically do not consistently practice the skills they learn in therapy;potentially limiting the mastery of these important skills and ultimately the efficacy of these interventions. We previously compared a skills-training program for middle-aged and older patients with schizophrenia and found that patients did not regularly comply with homework assignments, thereby limiting functional gains. We have developed a new skills-training intervention, called the """"""""Skills Training and Empowerment Program"""""""" (STEP) that incorporates communication technology (i.e., cellular phones) to help maximize compliance with homework and to improve generalization of skills to """"""""real-world"""""""" settings. The primary goal of this study is to examine the efficacy of our STEP program for improving functional outcome in a sample of middle-aged and older patients with schizophrenia. We will also examine whether this intervention is successful for increasing homework compliance, which we believe is a key mechanism linking skills training to increases in functional outcome. To accomplish our aims, we will enroll 240 middle-aged and older adults with schizophrenia and randomly assign them to receive 6-months of our new STEP intervention or 6-months of our original skills training intervention, known as the FAST program. Participants in the STEP program will attend 12 group-based intervention sessions (120 minutes each) emphasizing training in 6 functional domains (e.g., communication skills, financial management, medication management). Participants will also receive cellular phones and will receive 24 cell-phone sessions (20 minutes each) emphasizing homework compliance and problem-solving barriers to compliance. FAST participants will receive 24 group- based sessions (120 minutes each) emphasizing the same 6 functional domains. Both groups will receive 6 months of booster sessions to reinforce functional gains. Group differences in functional outcomes will be determined based upon assessments made at baseline, 6-, 12-, and 18-months post-baseline.

Public Health Relevance

Schizophrenia is among the most serious and most expensive mental disorders in terms of direct treatment costs, loss of productivity, and expenditures for public assistance, with an estimated annual cost to society of over $62 billion. The primary goal of this study is to examine the efficacy of a technology-enhanced Skills Training and Empowerment Program (called STEP) for improving functional outcomes in a sample of middle- aged and older patients with schizophrenia. If successful, this program may help improve overall well-being and functioning in a population that is traditionally noted to have significantly diminished capacity for learning, working, self-care, interpersonal relationships, and maintaining general living skills.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH084967-03
Application #
8055413
Study Section
Special Emphasis Panel (ZMH1-ERB-F (02))
Program Officer
Niederehe, George T
Project Start
2009-07-01
Project End
2014-01-31
Budget Start
2011-04-01
Budget End
2012-01-31
Support Year
3
Fiscal Year
2011
Total Cost
$545,966
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mausbach, Brent T; Tiznado, Denisse; Cardenas, Veronica et al. (2016) Validation of the UCSD Performance-based Skills Assessment (UPSA) in Hispanics with and without schizophrenia. Psychiatry Res 244:388-93
Depp, Colin A; Harmell, Alexandrea L; Vahia, Ipsit V et al. (2016) Neurocognitive and functional correlates of mobile phone use in middle-aged and older patients with schizophrenia. Aging Ment Health 20:29-35
Moore, Raeanne C; Harmell, Alexandrea L; Harvey, Philip D et al. (2015) Improving the understanding of the link between cognition and functional capacity in schizophrenia and bipolar disorder. Schizophr Res 169:121-127
Moore, Raeanne C; Fazeli, Pariya L; Patterson, Thomas L et al. (2015) UPSA-M: Feasibility and initial validity of a mobile application of the UCSD Performance-Based Skills Assessment. Schizophr Res 164:187-92
Mausbach, Brent T; Moore, Raeanne C; Davine, Taylor et al. (2013) The use of the theory of planned behavior to predict engagement in functional behaviors in schizophrenia. Psychiatry Res 205:36-42
Cardenas, Veronica; Abel, Stephanie; Bowie, Christopher R et al. (2013) When functional capacity and real-world functioning converge: the role of self-efficacy. Schizophr Bull 39:908-16
Moore, Raeanne C; Harmell, Alexandrea L; Ho, Jennifer et al. (2013) Initial validation of a computerized version of the UCSD Performance-Based Skills Assessment (C-UPSA) for assessing functioning in schizophrenia. Schizophr Res 144:87-92
Moore, Raeanne C; Davine, Taylor; Harmell, Alexandrea L et al. (2013) Using the repeatable battery for the assessment of neuropsychological status (RBANS) effort index to predict treatment group attendance in patients with schizophrenia. J Int Neuropsychol Soc 19:198-205
Moore, Raeanne C; Viglione, Donald J; Rosenfarb, Irwin S et al. (2013) Rorschach measures of cognition relate to everyday and social functioning in schizophrenia. Psychol Assess 25:253-63
Buck, Benjamin; Lysaker, Paul H (2013) Consummatory and anticipatory anhedonia in schizophrenia: stability, and associations with emotional distress and social function over six months. Psychiatry Res 205:30-5

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