This P01 develops and applies state-of-the-art methods to analyze existing but under-utilized drug abuse databases in collaboration with their owners. We address contemporary, theoretical, and applied issues in drug abuse research to understand intersections between substance abuse and AIDS risk behaviors as well as minority and gender-based health disparities. We work with dozens of investigators from drug &social policy, epidemiology, health sciences, medicine, nursing, psychiatry, psychology, public health, and social work who own exciting substance abuse data to develop models that test current theories, especially on epidemiology, prevention, intervention, and treatment of drug abuse, using modern multivariate methods to control for measurement errors, biases, and other confounds. The Models and Methods Project develops psychometric and statistical analytic techniques that hold special promise for improving the quality of drug abuse and AIDS research. The At-Risk Project studies substance abuse related data sets on vulnerable populations (substance abusers, homeless people, individuals who are HIV positive or who have AIDS, victims of domestic abuse, runaways, gang members, and others at high risk for AIDS or drug abuse) with methods to control sampling, measurement, distributional and other biases. The Community Project studies drug abuse etiology, adult consequences, HIV risk, intergenerational processes, general deviance, and related issues in large community-based samples, and develops and tests explanatory theories using models that permit separation of common from specific effects, control for artifacts, etc. The Core Project oversees and integrates all components, hosts visiting scholars, provides computer facilities, and sponsors a mentoring program for disadvantaged students. The substantive part of the Models Project and the At-Risk and Community Projects will be developing and testing integrative theories that can be applied across different populations. The findings from their studies will lead to greater understanding of precursors and concomitants of substance abuse and HIV/AIDS risk and transmission. In turn, these findings will guide development of effective interventions to reduce negative health outcomes and treatment disparities in community, ethnic, and vulnerable populations, and provide guidance on how these may be alleviated.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZDA1-RXL-E (03))
Program Officer
Deeds, Bethany
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University of California Los Angeles
Schools of Arts and Sciences
Los Angeles
United States
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Upchurch, Dawn M; Stein, Judith; Greendale, Gail A et al. (2015) A Longitudinal Investigation of Race, Socioeconomic Status, and Psychosocial Mediators of Allostatic Load in Midlife Women: Findings From the Study of Women's Health Across the Nation. Psychosom Med 77:402-12
Hunt, Tyler D; Bentler, Peter M (2015) Quantile lower bounds to reliability based on locally optimal splits. Psychometrika 80:182-95
Chin, Dorothy; Myers, Hector F; Zhang, Muyu et al. (2014) Who Improved in a Trauma Intervention for HIV-Positive Women with Child Sexual Abuse Histories? Psychol Trauma 6:152-158
Bentler, Peter M; Huang, Wenjing (2014) On Components, Latent Variables, PLS and Simple Methods: Reactions to Rigdon's Rethinking of PLS. Long Range Plann 47:138-145
Ibabe, Izaskun; Stein, Judith A; Nyamathi, Adeline et al. (2014) Predictors of substance abuse treatment participation among homeless adults. J Subst Abuse Treat 46:374-81
Campos, Belinda; Ullman, Jodie B; Aguilera, Adrian et al. (2014) Familism and psychological health: the intervening role of closeness and social support. Cultur Divers Ethnic Minor Psychol 20:191-201
Attonito, Jennifer; Dévieux, Jessy G; Lerner, Brenda D G et al. (2014) Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load. J Assoc Nurses AIDS Care 25:626-37
Rotheram-Borus, Mary Jane; Stein, Judith A; Rice, Eric (2014) Intervening on conflict, parental bonds, and sexual risk acts among adolescent children of mothers living with HIV. PLoS One 9:e101874
Moskowitz, Amanda; Stein, Judith A; Lightfoot, Marguerita (2013) The mediating roles of stress and maladaptive behaviors on self-harm and suicide attempts among runaway and homeless youth. J Youth Adolesc 42:1015-27
Brumsey, Ayesha Delany; Joseph, Nataria T; Myers, Hector F et al. (2013) Modeling the Relationship between Trauma and Psychological Distress among HIV-Positive and HIV-Negative Women. Psychol Trauma 5:69-76

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