Abstract

The overall goal of these experiments is to investigate the role(s) which exogenous GM1 gangliosides may play in ameliorating or preventing neural atrophy following peripheral auditory insults during maturation. specifically, mice and guinea pigs will be used to: 1) determine if ganglioside applications will negate changes in auditory brainstem responses following reversible neonatal conductive losses; 2) if ganglioside application will negate neuronal atrophy of superior olivary nuclei following a neonatal conductive loss; 3) to determine the effects of GM1 ganglioside and cochlear insults on the dendritic arborizations of cochlear nucleus neurons. These experiments will relate directly to the possible use of exogenous gangliosides in young patients with peripheral auditory disorders. Methods to be used include recording evoked auditory responses, animal surgery, and various light microscopic techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC000379-10
Application #
5209886
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2005) Development of low-frequency tone burst versus the click auditory brainstem response. J Am Acad Audiol 16:114-21; Quiz 122
Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2002) The effect of midline petrous apex lesions on tests of afferent and efferent auditory function. Ear Hear 23:224-34
Ruel, J; Bobbin, R P; Vidal, D et al. (2000) The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. Neuropharmacology 39:1959-73
Scott, D A; Drury, S; Sundstrom, R A et al. (2000) Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Gene 246:265-74
Li, L; Parkins, C W; Webster, D B (1999) Does electrical stimulation of deaf cochleae prevent spiral ganglion degeneration? Hear Res 133:27-39
Ruel, J; Chen, C; Pujol, R et al. (1999) AMPA-preferring glutamate receptors in cochlear physiology of adult guinea-pig. J Physiol 518 ( Pt 3):667-80
Scott, D A; Greinwald Jr, J H; Marietta, J R et al. (1998) Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene 215:461-9
Parker, M S; Larroque, M L; Campbell, J M et al. (1998) Novel variant of the P2X2 ATP receptor from the guinea pig organ of Corti. Hear Res 121:62-70
Chen, C; Skellett, R A; Fallon, M et al. (1998) Additional pharmacological evidence that endogenous ATP modulates cochlear mechanics. Hear Res 118:47-61
Skellett, R A; Cullen Jr, J K; Fallon, M et al. (1998) Conditioning the auditory system with continuous vs. interrupted noise of equal acoustic energy: is either exposure more protective? Hear Res 116:21-32

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