The continuing goals and theme of this program project grant are to develop and validate molecular biomarkers reflective of exposure, dose, effect and risk from environmental toxicants and translate these biomarkers as endpoints for the design and implementation of preventive interventions in populations. Underlying tenets that are based on public health evidence support the attainability of these goals, including the recognition that sub-sets of high-risk people exist within populations who are more susceptible to disease than their fellows. Thus, biomarker-based methods capable of identifying high-risk individuals with specificity and selectivity will greatly facilitate the implementation of a spectrum of targeted preventive interventions directed towards reducing environmentally-induced disease. The structure of the program project grant for renewal during years 2008-2013 includes four projects and two cores. The projects are: PROJECT 1: Chemical and Viral Biomarkers of Exposure and Risk in Hepatocellular Carcinogenesis (Groopman); PROJECT 2: Mycotoxin Biomarkers and Children's Health in Africa (Wild);PROJECT 3: Development, Validation and Application of Biomarkers for Alkylanilines (Tannenbaum and Wogan);PROJECT 4: Biomarker-Based Evaluation of Human Interventions (Kensler);Core A: Biostatistics/Epidemiology (Munoz);and Core B: Administration (Groopman).The four projects in this renewal application are integrated by our translational research strategies. Translational research is bidirectional in that it transforms scientific discoveries from the laboratory to clinical studies ("bench to bedside") or populations ("bench to at-risk communities") and in turn uses these findings in humans to inform the advancement of laboratory studies. In each project of this grant the laboratory research involves the development of state- of- the- art techniques of bioanalytical chemistry and novel technologies for analysis of DNA mutations and biomarkers, and the populations consist of at-risk groups for environmentally induced disease. The goal of each project is to contribute to the objective of improving health through the mitigation of environmental exposures and together we are working to implement practical interventions in at-risk communities using biomarkers as the metrics of efficacy.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Special Emphasis Panel (ZES1-SET-J (JG))
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Mcallister, Kimberly A
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Johns Hopkins University
Public Health & Prev Medicine
Schools of Public Health
United States
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Chawanthayatham, Supawadee; Thiantanawat, Apinya; Egner, Patricia A et al. (2015) Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change. Int J Cancer 136:1254-62
Castelino, Jovita M; Routledge, Michael N; Wilson, Shona et al. (2015) Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren. Mol Nutr Food Res 59:574-81
Castelino, Jovita M; Dominguez-Salas, Paula; Routledge, Michael N et al. (2014) Seasonal and gestation stage associated differences in aflatoxin exposure in pregnant Gambian women. Trop Med Int Health 19:348-54
Wu, Yan; Gan, Yu; Gao, Fumin et al. (2014) Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma. PLoS One 9:e94864
Erkekoglu, Pinar; Chao, Ming-Wei; Ye, Wenjie et al. (2014) Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds. Food Chem Toxicol 72:98-110
Chao, Ming-Wei; Erkekoglu, Pinar; Tseng, Chia-Yi et al. (2014) Intracellular generation of ROS by 3,5-dimethylaminophenol: persistence, cellular response, and impact of molecular toxicity. Toxicol Sci 141:300-13
Kensler, Kevin H; Slocum, Stephen L; Chartoumpekis, Dionysios V et al. (2014) Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci 139:293-300
Egner, Patricia A; Chen, Jian-Guo; Zarth, Adam T et al. (2014) Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila) 7:813-23
Chen, Jian-Guo; Kensler, Thomas W (2014) Changing rates for liver and lung cancers in Qidong, China. Chem Res Toxicol 27:3-6
Virk-Baker, Mandeep K; Nagy, Tim R; Barnes, Stephen et al. (2014) Dietary acrylamide and human cancer: a systematic review of literature. Nutr Cancer 66:774-90

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