There is great concern regarding the potential developmental and reproductive effects resulting from environmental exposure to endocrine disrupting compounds (EDCs). Recent population trends showing shifts in the age of puberty onset and progression have contributed to this concern, as has evidence for interrelationships between EDC exposures, overweight and obesity, and eadier onset of puberty. Early and late puberty onset are associated with social and psychological challenges and may indicate risk of current or future endocrine-related disorders. EDCs, such as phthalates and BPA, have been hypothesized to be associated with earlier puberty, while animal and human studies suggest exposure to lead and cadmium may be associated with delayed growth and puberty onset via endocrine-mediated pathways. There are a lack of longitudinal studies that have considered exposure to these agents, individually and as mixtures, and at multiple sensitive stages of development, in relation to physical growth and sexual maturation. The proposed study will address these gaps by expanding on pilot work ofthe University of Michigan (UM) Formative P20 Children's Center to undertake a more robust (N = 400) prospective assessment ofthe relationship between exposure to a select mixture of EDCs (phthalates, BPA, lead, and cadmium) and the tempo of physical growth and timing of sexual maturation in a long-standing longitudinal cohort study in Mexico. Existing data on life stage lead exposure and anthropometry (height, weight, BMI) 6-month intervals between birth and 5 years of age will be utilized, along with newly collected data. In the proposed study, children in the ongoing cohort will be re-recruited for two clinic visits (18 months apart) between the ages of 8 and 15 where Tanner stages (along with testicular volume among boys), anthropometry, and skjn fold thickness will be assessed by a clinician, a blood sample will be collected for analysis of lead and reproductive and thyroid hormones, and a urine sample will be collected for analysis of phthalates, BPA and cadmium. These same exposure measures will additionally be analyzed from samples collected at all 3 trimesters of pregnancy when the children were in utero. Four years of repeated self-reported Tanner stage

Public Health Relevance

Most, if not all, people in the United States are exposed to phthalates, BPA, and other potential endocrine disrupting chemicals (EDCs), including hormonally active heavy metals, on a daily basis. There is currently much concern that low-level environmental exposures to EDCs may be associated with the recently observed population trends of increased rates of obesity and earlier onset of puberty. Due to widespread exposure to these and other EDCs. the public health significance of this study could be enormous.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES022844-02
Application #
8689018
Study Section
Special Emphasis Panel (ZES1-LKB-K)
Project Start
2014-06-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$127,385
Indirect Cost
$42,042
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Anzai, Álvaro; Marcondes, Rodrigo R; Gonçalves, Thiago H et al. (2017) Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Sci Rep 7:13167
Perng, Wei; Hector, Emily C; Song, Peter X K et al. (2017) Metabolomic Determinants of Metabolic Risk in Mexican Adolescents. Obesity (Silver Spring) 25:1594-1602
Kochmanski, Joseph; Marchlewicz, Elizabeth H; Savidge, Matthew et al. (2017) Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice. Reprod Toxicol 68:154-163
Ferguson, Kelly K; Chen, Yin-Hsiu; VanderWeele, Tyler J et al. (2017) Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environ Health Perspect 125:488-494
Aung, Max T; Johns, Lauren E; Ferguson, Kelly K et al. (2017) Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environ Int 104:33-40
Sánchez, Brisa N; Kim, Sehee; Sammel, Mary D (2017) Estimators for longitudinal latent exposure models: examining measurement model assumptions. Stat Med 36:2048-2066
Yuan, Ye; Meeker, John D; Ferguson, Kelly K (2017) Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003-2004. Sci Total Environ 575:400-405
Zhou, Yan; Wang, Pei; Wang, Xianlong et al. (2017) Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis. Genet Epidemiol 41:70-80
Perng, Wei; Fernandez, Carmen; Peterson, Karen E et al. (2017) Dietary Patterns Exhibit Sex-Specific Associations with Adiposity and Metabolic Risk in a Cross-Sectional Study in Urban Mexican Adolescents. J Nutr 147:1977-1985
Perng, Wei; Watkins, Deborah J; Cantoral, Alejandra et al. (2017) Exposure to phthalates is associated with lipid profile in peripubertal Mexican youth. Environ Res 154:311-317

Showing the most recent 10 out of 68 publications