Abstract

The CORE laboratory provides all members of the Yale Center for Structural Biology facilities for the investigation of macromolecular systems by X-ray crystallography and X-ray small-angle scattering, including instruments for data collection and computers for data reduction and analysis. Since molecular graphics is vital to these activities, the CORE laboratory includes several such systems and is constantly upgrading its capabilities in this and all other areas of concern. In addition to the services it supplies to the users of the CORE laboratory, which includes instrument and computer maintenance and help with both kinds of devices, the CORE staff develops new instruments and procedures. The CSB web site, which enables users to access the programs and data bases that are generally useful to structural biologists, with documentation, is a recent example of a CORE laboratory development useful to the structural biology community both inside and outside Yale.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
2P01GM022778-26
Application #
6440492
Study Section
Project Start
1976-04-01
Project End
2006-03-31
Budget Start
Budget End
Support Year
26
Fiscal Year
2001
Total Cost
$174,159
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Wang, Jimin; Liu, Zheng; Crabtree, Robert H et al. (2018) On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation. Protein Sci 27:2051-2061
Sherlock, Madeline E; Sadeeshkumar, Harini; Breaker, Ronald R (2018) Variant Bacterial Riboswitches Associated with Nucleotide Hydrolase Genes Sense Nucleoside Diphosphates. Biochemistry :
Harris, Kimberly A; Zhou, Zhiyuan; Peters, Michelle L et al. (2018) A second RNA-binding protein is essential for ethanol tolerance provided by the bacterial OLE ribonucleoprotein complex. Proc Natl Acad Sci U S A 115:E6319-E6328
Greenlee, Etienne B; Stav, Shira; Atilho, Ruben M et al. (2018) Challenges of ligand identification for the second wave of orphan riboswitch candidates. RNA Biol 15:377-390
Mirihana Arachchilage, Gayan; Sherlock, Madeline E; Weinberg, Zasha et al. (2018) SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches. RNA Biol 15:371-378
Wang, Jimin (2018) Determination of chemical identity and occupancy from experimental density maps. Protein Sci 27:411-420
Sherlock, Madeline E; Sudarsan, Narasimhan; Breaker, Ronald R (2018) Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems. Proc Natl Acad Sci U S A 115:6052-6057
Harris, Kimberly A; Breaker, Ronald R (2018) Large Noncoding RNAs in Bacteria. Microbiol Spectr 6:
Yang, Yang; Kang, Dongwei; Nguyen, Laura A et al. (2018) Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife 7:
Vaidya, Anand T; Lomakin, Ivan B; Joseph, Newlyn N et al. (2017) Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation. J Mol Biol 429:2765-2771

Showing the most recent 10 out of 143 publications