The purpose of Core A is to further the aims ofthe Program Project grant by centralizing administrative activities. Centralization has several benefits. These include: 1) improved efficiency, 2) improved cost effectiveness and 3) enhanced professional interaction. Core A is an administrative core and will cover 1) administration, 2) bookkeeping, 3) secretarial support, 4) isotope administration, 5) statistical support, 6) consultation for programming and 7) consultation for echocardiography. Core A includes office support for all projects and the other three cores, blood gas and isotope service for sheep projects, statistical support and overall consultation by Professor Barker. One role ofthe administrative core will be to provide a suitable research environment for members of the Program Project. Core A will provide such an environment by means ofthe following: 1) Developmental Origins of Health and Disease Study Group. This group of investigators and students meet 2X/month under the coordination of Dr. Susan Bagby to discuss research. There are some 40 scientists who belong to this lively group. Susan was the primary planner for the 7th World Congress on the Developmental Origins of Health and Disease in Portland, September 18-21, 2011. 2) Try on For Size (TOPS) weekly research conference. This conference has an emphasis on cardiovascular biology and is attended by researchers from Cardiology, Pediatric Cardiology, Cardiac Surgery, Physiology &Pharmacology and Obstetrics &Gynecology. This conference has been running continuously for about 35 years. 3) Endothelial Chalk Talk monthly conference. This conference convenes all the people at OHSU who are interested in endothelial biology. This conference is run by Dr. Owen McCarty, PhD, an engineer from the Department of Biomedical Engineering. 4) Visiting Scientist Program: Every year well known scientists are invited to OHSU to exchange ideas and some are asked to evaluate the PPG and participate in an annual science day which highlights developmental heart disease research.

Public Health Relevance

Core A provides for the administrative needs ofthe Program Project and also enriches the academic environment by providing opportunities of scientific interaction with visiting guests and local scientists.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD034430-16A1
Application #
8521759
Study Section
Special Emphasis Panel (ZHD1-DSR-Z (41))
Project Start
Project End
Budget Start
2013-06-07
Budget End
2014-03-31
Support Year
16
Fiscal Year
2013
Total Cost
$188,318
Indirect Cost
$66,034
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Jonker, S S; Louey, S (2016) Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment. J Endocrinol 228:R1-18
Chadderdon, Scott M; Belcik, J Todd; Bader, Lindsay et al. (2016) Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes 65:2249-57
Barry, James S; Rozance, Paul J; Brown, Laura D et al. (2016) Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood) 241:839-47
Kolahi, Kevin; Louey, Samantha; Varlamov, Oleg et al. (2016) Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells. PLoS One 11:e0153522
Hashima, Jason N; Rogers, Vanessa; Langley, Stephen M et al. (2015) Fetal ventricular interactions and wall mechanics during ductus arteriosus occlusion in a sheep model. Ultrasound Med Biol 41:1020-8
Jonker, Sonnet S; Louey, Samantha; Giraud, George D et al. (2015) Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep. FASEB J 29:4346-57
Thornburg, K L (2015) The programming of cardiovascular disease. J Dev Orig Health Dis 6:366-76
Thornburg, Kent L; Marshall, Nicole (2015) The placenta is the center of the chronic disease universe. Am J Obstet Gynecol 213:S14-20
Boone-Heinonen, Janne; Messer, Lynne C; Fortmann, Stephen P et al. (2015) From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity. Prev Med 81:451-9
Jonker, Sonnet S; Giraud, George D; Espinoza, Herbert M et al. (2015) Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens. Am J Physiol Regul Integr Comp Physiol 308:R680-9

Showing the most recent 10 out of 91 publications