The Administrative Core is essential to the proper functioning of a program of this scope, and its major activities will continue to include supervision of programmatic interactions between the Cores and Projects 1, II and Ml. Through the central activities of the Administrative Core the overall operations of the Program Project Grant (PPG) will be managed including the coordiantion and evaluation of the progress of the 3 Projects and Cores, assistance with annual Progress Reports and management of budgetary matters. This core will provide the necessary contacts with and between the Internal and External Advisory Group (see Program Introduction for a detailed description of these groups), and will arrange for meetings of these committees as wel as more routine meetings amongst the Project Leaders and their lab personnel. The Core will also be responsible for appropriate recording activities including: IRB and lACUC submissions, abstract presentations, manuscript submissions, material transfer agreements and invention disclosures (via CHOP'S Technology Transfer Office).

Public Health Relevance

The Administrative Core (Core A) is critical to the overall synergistic runnig of the component Projects and Cores of the Program as well as in providing a common node for coordination and communication that has been, and will remain, an essential and vibrant part of the culture of this Program Project.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-N)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital of Philadelphia
United States
Zip Code
Muto, Akihiko; Ikeda, Shingo; Lopez-Burks, Martha E et al. (2014) Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet 10:e1004671
Zuin, Jessica; Franke, Vedran; van Ijcken, Wilfred F J et al. (2014) A cohesin-independent role for NIPBL at promoters provides insights in CdLS. PLoS Genet 10:e1004153
Krantz, Ian D (2014) Cohesin embraces new phenotypes. Nat Genet 46:1157-8
Visnes, T; Giordano, F; Kuznetsova, A et al. (2014) Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I. Chromosoma 123:239-52
Dorsett, Dale; Kassis, Judith A (2014) Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol 24:R535-9
Kaiser, Frank J; Ansari, Morad; Braunholz, Diana et al. (2014) Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance. Hum Mol Genet 23:2888-900
Slavin, Thomas P; Krantz, Ian (2013) Response to "germline mosaicism in Cornelia de Lange syndrome: dilemmas and risk figures" by Mariani et al. Am J Med Genet A 161A:1827
Jyonouchi, Soma; Orange, Jordan; Sullivan, Kathleen E et al. (2013) Immunologic features of Cornelia de Lange syndrome. Pediatrics 132:e484-9
Mannini, Linda; Cucco, Francesco; Quarantotti, Valentina et al. (2013) Mutation spectrum and genotype-phenotype correlation in Cornelia de Lange syndrome. Hum Mutat 34:1589-96
Schaaf, Cheri A; Misulovin, Ziva; Gause, Maria et al. (2013) Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes. PLoS Genet 9:e1003560

Showing the most recent 10 out of 47 publications