The Administrative Core will be responsible for the general administration of the Program Project grant. It will continue to be headed by Dr. Gregory Harshfield and Dr. David Pollock. The Core will also include individuals with supervisory responsibility over the reseach staff for the human components of each project. These include:1) the processing of human samples;2) subject recruitment and IRB approvals;and 3) nursing supervision for the pharmacologic studies.

Public Health Relevance

These activities will assure the Program Project grant will meet the goal of providing new and valuable information which can be translated into improved strategies for the prevention and treatment of essential hypertension

National Institute of Health (NIH)
Research Program Projects (P01)
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Heart, Lung, and Blood Program Project Review Committee (HLBP)
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Georgia Regents University
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Pollock, David M (2014) 2013 Dahl Lecture: American Heart Association council for high blood pressure research clarifying the physiology of endothelin. Hypertension 63:e110-7
Su, Shaoyong; Zhu, Haidong; Xu, Xiaojing et al. (2014) DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation. Twin Res Hum Genet 17:183-91
Riese, Harriëtte; Muñoz, Loretto M; Hartman, Catharina A et al. (2014) Identifying genetic variants for heart rate variability in the acetylcholine pathway. PLoS One 9:e112476
Hyndman, Kelly A; Ho, Dao H; Sega, Martiana F et al. (2014) Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3. Am J Physiol Heart Circ Physiol 307:H803-9
Su, Shaoyong; Wang, Xiaoling; Kapuku, Gaston K et al. (2014) Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults. Hypertension 64:201-7
Jin, Chunhua; Jeon, Yejoo; Kleven, Daniel T et al. (2014) Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome. J Pharmacol Exp Ther 351:467-73
Kittikulsuth, W; Sullivan, J C; Pollock, D M (2013) ET-1 actions in the kidney: evidence for sex differences. Br J Pharmacol 168:318-26
Loria, Analia S; Brands, Michael W; Pollock, David M et al. (2013) Early life stress sensitizes the renal and systemic sympathetic system in rats. Am J Physiol Renal Physiol 305:F390-5
Spradley, F T; Kang, K-T; Pollock, J S (2013) Short-term hypercaloric diet induces blunted aortic vasoconstriction and enhanced vasorelaxation via increased nitric oxide synthase 3 activity and expression in Dahl salt-sensitive rats. Acta Physiol (Oxf) 207:358-68
Kittikulsuth, Wararat; Looney, Stephen W; Pollock, David M (2013) Endothelin ET(B) receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet. Clin Exp Pharmacol Physiol 40:362-70

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