A.
Specific Aims The Administrative Core (AC) will provide support for planning, execution, and evaluation of the proposed research. The AC will support all administrative activities relating to the five projects and high throughput core enabling cohesion among the projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL081587-08
Application #
8438336
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
8
Fiscal Year
2013
Total Cost
$158,585
Indirect Cost
$61,709
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Fuster, José J; Zuriaga, María A; Ngo, Doan Thi-Minh et al. (2015) Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 64:1235-48
Romero, Freddy; Shah, Dilip; Duong, Michelle et al. (2015) A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis. Am J Respir Cell Mol Biol 53:74-86
Kikuchi, Ryosuke; Nakamura, Kazuto; MacLauchlan, Susan et al. (2014) An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nat Med 20:1464-71
Ngo, Doan T M; Farb, Melissa G; Kikuchi, Ryosuke et al. (2014) Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity. Circulation 130:1072-80
Tan, Peng H; Tyrrell, Helen E J; Gao, Liquan et al. (2014) Adiponectin receptor signaling on dendritic cells blunts antitumor immunity. Cancer Res 74:5711-22
Hartman, Mor-Li; Shirihai, Orian S; Holbrook, Monika et al. (2014) Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc Med 19:67-74
Nakamura, Kazuto; Fuster, José J; Walsh, Kenneth (2014) Adipokines: a link between obesity and cardiovascular disease. J Cardiol 63:250-9
Shimizu, Ippei; Aprahamian, Tamar; Kikuchi, Ryosuke et al. (2014) Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest 124:2099-112
Yoshida, Sumiko; Fuster, José Javier; Walsh, Kenneth (2014) Adiponectin attenuates abdominal aortic aneurysm formation in hyperlipidemic mice. Atherosclerosis 235:339-46
Parker-Duffen, Jennifer L; Walsh, Kenneth (2014) Cardiometabolic effects of adiponectin. Best Pract Res Clin Endocrinol Metab 28:81-91

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