The Human Subjects Core will provide a core resource for the recruitment and characterization of human subjects and the careful collection of biospecimens from these subjects. Recruiting human subjects for mechanism-oriented clinical research protocols requires well-developed systems to ensure successful subject recruitment and the collection of high quality biospecimens from well-characterized human subjects. Dr John Fahy, director of the UCSF Airway Clinical Research Center (UCSF-ACRC), and Dr Prescott Woodruff (associate director of the UCSF-ACRC), along with a team of research coordinators, have considerable experience in all aspects of these systems. The core will have three specific Aims.
Aim 1 will be to recruit and enroll healthy and asthmatic subjects for study protocols designed to support the need of the three PPG projects.
Aim 2 will be to collect high quality biospecimens from healthy and asthmatic subjects using systems and methods which ensure compliance with regulations.
Aim 3 will be to manage IRB-related approvals and other regulatory paperwork for human research related to the three projects.

Public Health Relevance

Core B will provide a resource for recruiting healthy and asthmatic subjects to clinical studies which will support the projects in this PPG. The core will collect high quality biospecimens from well-characterized healthy and asthmatic subjects using systems and methods which ensure compliance with regulations. The core will also manage IRB-related approvals and other regulatory paperwork for human research related to the three projects.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL107202-03
Application #
8676914
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mohapatra, A; Van Dyken, S J; Schneider, C et al. (2016) Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol 9:275-86
Gordon, Erin D; Locksley, Richard M; Fahy, John V (2016) Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med 193:935-6
von Moltke, Jakob; Ji, Ming; Liang, Hong-Erh et al. (2016) Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529:221-5
Fahy, John V (2016) Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress. Ann Am Thorac Soc 13 Suppl 1:S78-82
Pua, Heather H; Steiner, David F; Patel, Sana et al. (2016) MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity 44:821-32
Wesolowska-Andersen, Agata; Seibold, Max A (2016) Is the Road to Precision Medicine in Chronic Lung Disease Paved with Degraded Chitin? Am J Respir Crit Care Med 193:107-8
Gordon, Erin D; Simpson, Laura J; Rios, Cydney L et al. (2016) Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A 113:8765-70
Gordon, Erin D; Palandra, Joe; Wesolowska-Andersen, Agata et al. (2016) IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight 1:e87871
Reber, Laurent L; Fahy, John V (2016) Mast cells in asthma: biomarker and therapeutic target. Eur Respir J 47:1040-2
Ramstein, Joris; Broos, Caroline E; Simpson, Laura J et al. (2016) IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med 193:1281-91

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