The Neuroimaging Core functions as a resource for instrumentation, data acquisition, processing, and analysis in support of the experiments conducted in Projects 1 and 2. This core will provide cutting edge neuroimaging advances and computational tools, which are important to optimize data processing. The director of this core, Dr. Thomas Liu, is also the Director of the UCSD Center for Functional Magnetic Resonance Imaging (fMRI) and, therefore, brings to bear the significant existing infrastructure of the UCSD Center for fMRI for this proposal. Moreover, Dr. Liu's expertise in perfusion imaging will help provide analysis approaches to determine whether general differences in blood perfusion across groups account for BOLD fMRI differences during the interoception and cue reactivity tasks, and will ensure high quality neuroimaging data.
The specific aims of this core are: (1) To utilize neuroimaging procedures developed at the UCSD Center for fMRI to provide continued quality control of ongoing experiments.
This aim will help us to optimize our imaging analyses steps and to have explicit quality control implemented similar to that of other large-scale fMRI studies. (2) To provide a core computational infrastructure to standardize and optimize the neuroimaging pipeline. This will help us to compare images obtained for Project 1 with those of Project 2 to better delineate the degree of dysregulated interoception across the addiction cycle. (3) To provide basic and advanced training for all CIDIA associated investigators for neuroimaging acquisition and analysis.
This aim i s focused primarily on combine educational and training activities in the Neuroimaging Core so as to economize our ability to bring in new investigators, maintain high level of expertise among neuroimaging investigators, and incorporate new insights from the literature to optimize the image analysis pathway. By accomplishing these aims, the core will primarily support Projects 1 and 2, which will make it easier and more appropriate to compare data sets across projects. However, we also envision that this core will begin to explore the possibility for future animal neuroimaging, which could be done in a full center extension of this initial project.

Public Health Relevance

Having a centralized core for neuroimaging data helps ensure that the data acquisition, processing, and analysis is done according to the latest standards in this quickly changing field of functional magnetic resonance imaging. Moreover, we hope this core will be a resource for new investigators that are interested in studying how the brain controls the urge to use drugs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA027843-04
Application #
8444671
Study Section
Special Emphasis Panel (ZDA1-MXS-M)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
4
Fiscal Year
2013
Total Cost
$190,799
Indirect Cost
$44,099
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Stewart, Jennifer L; Juavinett, Ashley L; May, April C et al. (2015) Do you feel alright? Attenuated neural processing of aversive interoceptive stimuli in current stimulant users. Psychophysiology 52:249-62
Paulus, Martin P; Stewart, Jennifer L (2014) Interoception and drug addiction. Neuropharmacology 76 Pt B:342-50
Gowin, Joshua L; Harle, Katia M; Stewart, Jennifer L et al. (2014) Attenuated insular processing during risk predicts relapse in early abstinent methamphetamine-dependent individuals. Neuropsychopharmacology 39:1379-87
Stewart, Jennifer L; May, April C; Poppa, Tasha et al. (2014) You are the danger: attenuated insula response in methamphetamine users during aversive interoceptive decision-making. Drug Alcohol Depend 142:110-9
Mackey, Scott; Stewart, Jennifer L; Connolly, Colm G et al. (2014) A voxel-based morphometry study of young occasional users of amphetamine-type stimulants and cocaine. Drug Alcohol Depend 135:104-11
Gowin, Joshua L; Stewart, Jennifer L; May, April C et al. (2014) Altered cingulate and insular cortex activation during risk-taking in methamphetamine dependence: losses lose impact. Addiction 109:237-47
Gowin, Joshua L; Mackey, Scott; Paulus, Martin P (2013) Altered risk-related processing in substance users: imbalance of pain and gain. Drug Alcohol Depend 132:13-21
Mackey, Scott; Paulus, Martin (2013) Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants? Neurosci Biobehav Rev 37:300-16
Paulus, Martin P (2013) The breathing conundrum-interoceptive sensitivity and anxiety. Depress Anxiety 30:315-20
Stewart, Jennifer L; Flagan, Taru M; May, April C et al. (2013) Young adults at risk for stimulant dependence show reward dysfunction during reinforcement-based decision making. Biol Psychiatry 73:235-41

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