Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37CA051497-15
Application #
6611776
Study Section
Special Emphasis Panel (NSS)
Program Officer
Perry, Mary Ellen
Project Start
1990-01-01
Project End
2007-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
15
Fiscal Year
2004
Total Cost
$449,625
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Dang, Chi Van; Kim, Jung-Whan (2018) Convergence of Cancer Metabolism and Immunity: an Overview. Biomol Ther (Seoul) 26:4-9
Le, Anne; Stine, Zachary E; Nguyen, Christopher et al. (2014) Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter. Proc Natl Acad Sci U S A 111:12486-91
Dang, Chi V (2010) Enigmatic MYC Conducts an Unfolding Systems Biology Symphony. Genes Cancer 1:526-531
Dang, Chi V (2010) Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 70:859-62
Seltzer, Meghan J; Bennett, Bryson D; Joshi, Avadhut D et al. (2010) Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 70:8981-7
Gao, Ping; Tchernyshyov, Irina; Chang, Tsung-Cheng et al. (2009) c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458:762-5
Dang, Chi V (2009) MYC, microRNAs and glutamine addiction in cancers. Cell Cycle 8:3243-5
Dang, Chi V (2009) PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci Signal 2:pe75
Gao, Ping; Zhang, Huafeng; Dinavahi, Ramani et al. (2007) HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 12:230-8
Zhang, Huafeng; Gao, Ping; Fukuda, Ryo et al. (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11:407-20

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