The ubiquitous exposure to environmental contaminants in the US population, combined with the accumulating evidence of immediate and latent harm caused by in utero exposures, increases the need to better understand fetal exposure to chemicals during key stages of development. For most environmental chemicals, studies that examine the relationship between maternal and fetal exposure prior to birth are scarce, largely due to the challenges of collecting biological specimens, in particular umbilical cord blood and amniotic fluid. Meanwhile, questions about the degree to which chemicals cross the placenta, accumulate in the fetus and are metabolized by the pregnant woman and fetus remain unanswered. There is a critical need for human studies that are designed specifically to answer these questions. In this project we will generate unprecedented data on chemical exposures during the second trimester of pregnancy, when certain aspects of fetal development are particularly vulnerable to disruption. Specifically, we will 1) describe fetal and maternal exposure to BPA during the second trimester of pregnancy, and 2) explore the feasibility and accuracy of using maternal biological monitoring results to predict fetal exposure. To do this, we will initiate the collection of maternal and fetal biological specimens from women undergoing elective second-trimester pregnancy terminations. We will measure, analyze and compare levels of the chemical bisphenol A (BPA) in these samples, including a comparison of maternal and fetal metabolism of BPA. The data produced by this research project will fill key gaps in our understanding of fetal exposure to and capacity to detoxify BPA. These findings will inform and strengthen future studies of BPA effects on fetal development. In addition, with the successful implementation of this study, we will be poised to rapidly broaden the PEEC Formative Center to explore exposure to and effects of other important environmental contaminants.
We will substantially advance understanding of human maternal and fetal exposures to Bisphenol A (BPA) by producing original data on BPA levels in pregnant women and fetal tissues and fetal capacity to metabolize and detoxify BPA. Insights gained about the differences in maternal and fetal exposures and the role of fetal metabolism will be applicable to other environmental chemicals with similar sources of exposure and that are detoxified through the same nathw/avs.
|Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2016) Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environ Health 15:43|
|Morgan, Rebecca L; Thayer, Kristina A; Bero, Lisa et al. (2016) GRADE: Assessing the quality of evidence in environmental and occupational health. Environ Int 92-93:611-6|
|Vandenberg, Laura N; Ågerstrand, Marlene; Beronius, Anna et al. (2016) A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environ Health 15:74|
|Gerona, Roy R; Pan, Janet; Zota, Ami R et al. (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 15:50|
|Johnson, Paula I; Sutton, Patrice; Atchley, Dylan S et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1028-39|
|Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25|
|Lam, Juleen; Koustas, Erica; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1040-51|
|Woodruff, Tracey J; Sutton, Patrice (2014) The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007-14|
|Stotland, Naomi E; Sutton, Patrice; Trowbridge, Jessica et al. (2014) Counseling patients on preventing prenatal environmental exposures--a mixed-methods study of obstetricians. PLoS One 9:e98771|
|Koustas, Erica; Lam, Juleen; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015-27|
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