As natural probes of living systems, viruses have provided some of the most fundamental insights into basic biological processes: DMA replication, transcription and translation, cell signaling pathways, oncogenes and tumor suppressors, and host immune defense. Their importance as agents of biowarfare and emerging infectious diseases, together with their potential for use as novel therapeutics in an age of molecular medicine, provided the impetus for the creation of the Center of Molecular and Tumor Virology (CMTV) at Louisiana State University Health Sciences Center- Shreveport in 2003. After four years of COBRE support we have laid the foundation for a world-class virology center at an institution without a strong research tradition. The CMTV was built by aggressive faculty recruitment, diligent mentoring of young investigators, extensive partnering to create a sustainable research infrastructure, and melding COBRE goals with a newly formulated University strategic plan for long-range research development. With the CMTV now providing an element of strength that can be used to enhance the overall research mission campus-wide, we propose to broaden the impact of the requested COBRE support by 1) expansion of the CMTV beyond its original single departmental base to create synergistic scientific collaborations that are interdisciplinary, promote clinical applications of research findings, and involve three universities in North Louisiana and integrate COBRE and INBRE programs;2) mentored development of investigators previously funded by the COBRE, together with backing for five new Project Leaders whose multidisciplinary research is interconnected by a shared theme addressing the molecular basis for viral pathogenesis;3) enhancement of research infrastructure by the creation of COBRE Cores that fully integrate with and/or complement existing shared services. Together with the substantive University commitment to a revitalized mission that embraces biomedical research, this final phase of CMTV development will create a Center that is responsive to overall goals of the COBRE initiative and NIH Roadmap and is rooted in excellent basic science investigation with a translational emphasis that favors application of hypothesis-driven investigation from bench to bedside and back.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Douthard, Regine
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University Hsc Shreveport
Schools of Medicine
United States
Zip Code
Anandharaj, Arunkumar; Ekshyyan, Oleksandr; Jia, Yali et al. (2016) EBV and not HPV sensitizes tobacco-associated head and neck cancer cell line FaDu to radiotherapy. Acta Otolaryngol 136:354-62
DiGiuseppe, Stephen; Bienkowska-Haba, Malgorzata; Sapp, Martin (2016) Human Papillomavirus Entry: Hiding in a Bubble. J Virol 90:8032-5
Kim, Seong K; Shakya, Akhalesh K; O'Callaghan, Dennis J (2016) Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence. Virus Res 211:222-32
DiGiuseppe, Stephen; Luszczek, Wioleta; Keiffer, Timothy R et al. (2016) Incoming human papillomavirus type 16 genome resides in a vesicular compartment throughout mitosis. Proc Natl Acad Sci U S A 113:6289-94
Kim, Jung Heon; Collins-McMillen, Donna; Caposio, Patrizia et al. (2016) Viral binding-induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes. Proc Natl Acad Sci U S A 113:8819-24
Kim, Seong K; Shakya, Akhalesh K; Kim, Seongman et al. (2016) Functional Characterization of the Serine-Rich Tract of Varicella-Zoster Virus IE62. J Virol 90:959-71
DiGiuseppe, Stephen; Bienkowska-Haba, Malgorzata; Guion, Lucile G et al. (2016) Cruising the cellular highways: How human papillomavirus travels from the surface to the nucleus. Virus Res :
Wang, Hong-Bo; Zhang, Hua; Zhang, Jing-Ping et al. (2015) Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells. Nat Commun 6:6240
Martinez, Nicholas E; Sato, Fumitaka; Kawai, Eiichiro et al. (2015) Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun 43:86-97
Sato, Fumitaka; Martinez, Nicholas E; Stewart, Elaine Cliburn et al. (2015) "Microglial nodules" and "newly forming lesions" may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model. BMC Neurol 15:219

Showing the most recent 10 out of 62 publications