. NGS technologies have transformed the way in which research is conducted. The sheer scale of inquiry has been expanded to the extent that whole genomes and transcriptomes of cohorts of individuals can be surveyed in a single experiment. Moreover, sequencing can be used to probe biological phenomena at multiple levels of regulation, including germ-line variation, DNA methylation, mRNA expression and splice form abundance, microRNA expression, and chromatin structure exploration. NGS is also displacing other technologies, in particular the use of fixed-content chips for genotyping. NGS is being applied in every field of biological research, and will be an essential tool in the development of individualized medicine. Sequence data without sophisticated bioinformatics is essentially useless. Having a technology partner consisting of an experienced team of bioinformatics researchers and analysts, co-located with the sequencing operation is unprecedented in New Mexico. The SBC will continue to provide the network turn-key access to discovery? enabling sequencing and bioinformatics.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
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New Mexico State University Las Cruces
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Cuaron, Jesus A; Dulal, Santosh; Cooke, Peter H et al. (2014) The isolation of Staphylococcus aureus tea tree oil-reduced susceptibility mutants. Phytother Res 28:1240-5
Flook, Adam M; Yang, Jianquan; Miao, Yubin (2014) Substitution of the Lys linker with the ?-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated ?-melanocyte stimulating hormone peptides. J Med Chem 57:9010-8
Dziewanowska, Katarzyna; Settles, Matthew; Hunter, Samuel et al. (2014) Phase variation in Myxococcus xanthus yields cells specialized for iron sequestration. PLoS One 9:e95189
Astashkin, Andrei V; Chen, Li; Zhou, Xixi et al. (2014) Pulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective. J Phys Chem A 118:6864-72
McGraw, J; Tatipelli, V K; Feyijinmi, O et al. (2014) A semi-automated method for purification of milligram quantities of proteins on the QIAcube. Protein Expr Purif 96:48-53
Vaughan, Roger A; Gannon, Nicholas P; Garcia-Smith, Randi et al. (2014) ?-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer 13:14
Lu, Jie; Hathaway, Helen J; Royce, Melanie E et al. (2014) Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett 24:725-30
Yang, Jianquan; Flook, Adam M; Feng, Changjian et al. (2014) Linker modification reduced the renal uptake of technetium-99m-labeled Arg-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptide. Bioorg Med Chem Lett 24:195-8
Diallo, Diawo; Sall, Amadou A; Diagne, Cheikh T et al. (2014) Patterns of a sylvatic yellow fever virus amplification in southeastern Senegal, 2010. Am J Trop Med Hyg 90:1003-13
Vshyvenko, Sergey; Reisenauer, Mary Rose; Rogelj, Snezna et al. (2014) Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide. Bioorg Med Chem Lett 24:4236-8

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