The molecular mechanisms of microtubule morphogenesis and their regulation are addressed by this application. Specifically, this proposal focuses on Rbl2p, a S. cerevisiae protein involved at some basic level in the pathway from tubulin gene-products to functional microtubules. Rbl2p was identified by this group by its ability to suppress the deleterious effects of overexpression of b-tubulin. It is similar in sequence to murine cofactor A which has also been implicated in microtubule assembly. Other gene-products related to microtubule assembly and/or function will also be examined.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051615-02
Application #
2459589
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139