The objective of this revised application is to create a Center of Biomedical Research Excellence in Obesity and Cardiovascular Disease (COCVD) to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population, and to use this focus as a platform to develop promising junior investigators and enhance their success at competing for NIH grant support. We will achieve this objective by (1) assembling a group of established extramurally-funded scientists who will mentor faculty serving as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease, (2) providing a variety of mentoring approaches that will facilitate the development of research projects by investigators, leading to independent NIH-funded research, (3) developing and supporting shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease, (4) providing pilot grants for new projects focused on obesity and cardiovascular diseases, (5) facilitating symposia, seminars and meetings of participants researching obesity and cardiovascular diseases, (6) focusing on the research of the center at retreats dedicated to evaluating progress by investigators studying obesity and cardiovascular diseases, (7) strategically hiring promising new faculty to develop a critical mass of productive physician and basic scientists studying obesity and cardiovascular diseases. Five investigators, representing both physician and basic scientists, will serve as principal investigators on research projects that address a central hypothesis and that utilize a common model of diet-induced obesity to study obesity-induced hypertension, atherosclerosis, and platelet dysfunction/vascular inflammation. The central hypothesis of this revised proposal is that obesity induces changes in the production and release of adiopkines and other inflammatory mediators to promote cardiovascular diseases. Each project addresses aspects of this hypothesis using a common model of diet-induced obesity, and the projects synergize through their focus on adipokines, inflammation and through coordinate development of multiple cardiovascular diseases. The proposed structure and mentoring mechanisms will meet the need of increasing NIH funded research, and will develop a multi-disciplinary Center around the clinically significant area of obesity and cardiovascular disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Murphy, Margaret O; Petriello, Michael C; Han, Sung Gu et al. (2016) Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci Pollut Res Int 23:2201-11
Lolay, Georges A; Abdel-Latif, Ahmed K (2016) Trauma induced myocardial infarction. Int J Cardiol 203:19-21
Park, Se-Hyung; Liu, Zun; Sui, Yipeng et al. (2016) IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity. Diabetes 65:1616-29
Adamiak, M; Poniewierska-Baran, A; Borkowska, S et al. (2016) Evidence that a lipolytic enzyme-hematopoietic-specific phospholipase C-β2-promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes. Leukemia 30:919-28
Pumphrey, Ashley; Yang, Zhengshi; Ye, Shaojing et al. (2016) Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging. NMR Biomed 29:74-83
Platt, Kristen M; Charnigo, Richard J; Shertzer, Howard G et al. (2016) Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice. J Diet Suppl 13:473-86
Wu, Chia-Hua; Mohammadmoradi, Shayan; Thompson, Joel et al. (2016) Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. Hypertension 68:213-9
Howatt, Deborah A; Balakrishnan, Anju; Moorleghen, Jessica J et al. (2016) Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol 36:835-45
Li, Jing; Song, Jun; Zaytseva, Yekaterina Y et al. (2016) An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature 533:411-5
Hamlet, Sean M; Haggerty, Christopher M; Suever, Jonathan D et al. (2016) Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. J Magn Reson Imaging :

Showing the most recent 10 out of 161 publications