Prostate cancer incidence and mortality rates in African-American men are highest in the world compared to the general population. The Center of Cancer Research and Therapeutic Development (CCRTD) uses a broad approach of examining the many factors that cause this health disparity. CCRTD is dedicated to the expansion of its educational and community based-participatory research agenda in the African-American community to build awareness about the prevalence and prevention of prostate cancer, as well as the benefits of early detection. We are proposing continued support to develop and initiate programs in our Community Outreach/Education Core, which will provide information on prostate cancer prevention, screening and treatment, with an emphasis on racial and ethnic disparities. CCRTD has planned, implemented and sponsored several outreach initiative aimed at educating African-American men in the metropolitan Atlanta area promoting prostate cancer awareness and annual testing for prostate cancer through health fairs, town hall meetings, seminars, and media outlets. The Core has drawn support from community partners which, include: Division of Communication Arts, Department of Athletics, Midtown Urology Educational Foundation, The Prostate Net and Second Opinion Society. Collaborations will continue and serve as a catalyst for providing unique advantages for community outreach and educational programs developed by CCRTD. The Core intends to expand the community outreach capacity, such that cancer information is relevantly disseminated to diverse communities. In addition, CCRTD will develop instruments and statistical tools to measure activity outcomes.
The specific aims of CCRTD are: 1) To foster, conduct, and apply results of culturally relevant and appropriate community-based participatory research. 2) To increase the evidence-based community education and outreach that will help strengthen awareness for prevention, early detection and treatment of prostate cancer, which disproportionately affects African- American communities. 3) To expand and maintain media outlets for purposes of providing prostate cancer related educational information to the African-American community.

Public Health Relevance

Utilizing community outreach research to enhance and develop widely accessible, outreach and media methods to assist individuals, specifically African-American men in making informed decisions about prostate cancer.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN (04))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Clark Atlanta University
United States
Zip Code
Sheng, Xiumei; Wang, Zhengxin (2016) Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation. BMC Cancer 16:567
Sheng, Xiumei; Bowen, Nathan; Wang, Zhengxin (2016) GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer 15:25
Bhosle, Sushma M; Hunt, Aisha; Chaudhary, Jaideep (2016) A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biol Proced Online 18:9
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H; Morton, Derrick J et al. (2016) ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun 478:60-6
Millena, Ana Cecilia; Vo, BaoHan T; Khan, Shafiq A (2016) JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation. J Biol Chem 291:17964-76
Patel, Divya; Morton, Derrick J; Carey, Jason et al. (2015) Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta 1855:92-103
Chinaranagari, Swathi; Sharma, Pankaj; Bowen, Nathan J et al. (2015) Prostate cancer epigenome. Methods Mol Biol 1238:125-40
Henderson, Veronica; Smith, Basil; Burton, Liza J et al. (2015) Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adh Migr 9:255-64
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Burton, Liza J; Smith, Basil A; Smith, Bethany N et al. (2015) Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis 36:1019-27

Showing the most recent 10 out of 45 publications