This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Selenoproteins contain the trace element, selenium (Se), incorporated in the 21st amino acid selenocysteine. Selenoprotein P (SelP) has strong antioxidant properties and can chelate toxic metals. Targeted disruption of SelP results in neurological deficits including spatial memory deficiency. We recently reported that selenoprotein P (SelP) is associated with Alzheimer's pathology (Bellinger et al., J. Alzheimers Dis., 2008). This project will investigate the possible neuroprotective role for SelP and determine its importance in synaptic function and memory. We hypothesize that SelP protects neuronal function though direct antioxidant properties as well as supplying selenium for synthesis of other selenoproteins. We will test this hypothesis with the following aims: 1) determine the role of SelP in Alzheimer's pathology by characterizing SelP-expressing cells associated with plaques, and determining if SelP protects against amyloid toxicity, 2) determine the role of SelP in modulating synaptic changes by investigating synaptic physiology in SelP null mice, and 3) determine if brain-specific overexpression of SelP alters synaptic physiology. This research project will clarify the role of SelP in normal neurological function and its possible preventative role in neurodegenerative disorders.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016467-10
Application #
8360705
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
10
Fiscal Year
2011
Total Cost
$68,856
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Kaholokula, Joseph Keawe'aimoku; Antonio, Mapuana C K; Ing, Claire K Townsend et al. (2017) The effects of perceived racism on psychological distress mediated by venting and disengagement coping in Native Hawaiians. BMC Psychol 5:2
Yu, Xufen; Zhang, Mingming; Annamalai, Thirunavukkarasu et al. (2017) Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors. Eur J Med Chem 125:515-527
Jarvi, Susan I; Bianchi, Kiara R; Farias, Margaret Em et al. (2016) Characterization of class II ? chain major histocompatibility complex genes in a family of Hawaiian honeycreepers: 'amakihi (Hemignathus virens). Immunogenetics 68:461-475
Sato, Brittany L; Collier, Eric S; Vermudez, Sheryl Anne et al. (2016) Human amnion mesenchymal cells are pro-inflammatory when activated by the Toll-like receptor 2/6 ligand, macrophage-activating lipoprotein-2. Placenta 44:69-79
Sun, Zuyue; Schriewer, Jill; Tang, Mingxin et al. (2016) The TGF-? pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol 90:129-38
Miklossy, Gabriella; Youn, Ui Joung; Yue, Peibin et al. (2015) Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem 58:7734-48
Youn, Ui Joung; Sripisut, Tawanun; Park, Eun-Jung et al. (2015) Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett 25:4719-23
Panee, Jun (2015) Potential Medicinal Application and Toxicity Evaluation of Extracts from Bamboo Plants. J Med Plant Res 9:681-692
Panee, Jun; Pang, Xiaosha; Munsaka, Sody et al. (2015) Independent and co-morbid HIV infection and Meth use disorders on oxidative stress markers in the cerebrospinal fluid and depressive symptoms. J Neuroimmune Pharmacol 10:111-21
Rueli, Rachel H L H; Parubrub, Arlene C; Dewing, Andrea S T et al. (2015) Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain. J Alzheimers Dis 44:379-83

Showing the most recent 10 out of 142 publications