This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Inflammation is central to our fighting against pathogens, but if not controlled in a proper manner, can contributes to disease including cancers. Population based studies showed that long-term use of non-steroidal anti-inflammatory drugs reduces the risk of several cancers. Moreover, most solid tumors contain many inflammatory cells that play an important role in tumor progression. However, importance of inflammatory cells in human B lymphoma progression has not been recognized until recently. Microarray gene expression profiling studies have identified gene signatures predictive of tumor behavior and patient outcome in B lymphomas. Surprisingly, these data uncovered a strong role for immune response in the pathogenesis and progression of B lymphoma by identifying 2 prognostic signatures based upon nonmalignant tumor infiltrating cells rather than characteristics of the tumor cells. These two signatures, one reflecting expression from macrophage and the other reflecting expression from T cells, have been shown to be associated with patient survival. Hence, understanding the roles of host immune cells in B lymphoma progression deserves further exploration and would potentially lead to a new therapy targeting microenvironment in B cell lymphoma. In this study, we propose to determine the role of lymphoma associated macrophages (LAM) in B lymphoma progression.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021970-07
Application #
8360454
Study Section
Special Emphasis Panel (ZRR1-CR-B (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
7
Fiscal Year
2011
Total Cost
$105,968
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Sanchez, Maria Dulfary; Ochoa, Augusto C; Foster, Timothy P (2016) Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways. Antiviral Res 132:13-25
Dai, Lu; Bai, Lihua; Lin, Zhen et al. (2016) Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget 7:47052-47060
Schieffelin, John; Moses, Lina M; Shaffer, Jeffrey et al. (2016) Clinical validation trial of a diagnostic for Ebola Zaire antigen detection: Design rationale and challenges to implementation. Clin Trials 13:66-72
Dai, Lu; Trillo-Tinoco, Jimena; Cao, Yueyu et al. (2015) Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma. Blood 126:2821-31
Dai, Lu; Chen, Yihan; Bonstaff, Karlie et al. (2015) Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients. Cancer Lett 362:158-66
Dai, Lu; Trillo-Tinoco, Jimena; Bai, Aiping et al. (2015) Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression. Oncotarget 6:24246-60
Geng, Degui; Kaczanowska, Sabina; Tsai, Alexander et al. (2015) TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity. Cancer Res 75:1959-71
Fletcher, Matthew; Ramirez, Maria E; Sierra, Rosa A et al. (2015) l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. Cancer Res 75:275-83
Qin, Zhiqiang; Peruzzi, Francesca; Reiss, Krzysztof et al. (2014) Role of host microRNAs in Kaposi's sarcoma-associated herpesvirus pathogenesis. Viruses 6:4571-80
Sierra, Rosa A; Thevenot, Paul; Raber, Patrick L et al. (2014) Rescue of notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancer. Cancer Immunol Res 2:800-11

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