The Oregon Alzheimer's Disease Center Biomarkers and Genetics Core was established in order to promote research utilizing genetic, plasma, and cerebrospinal fluid biomarkers of Alzheimer's disease and relevant mechanisms.
The Specific Aims are: 1) To obtain and make available for research, biomarker specimens (DNA. plasma, and CSF) from OADC subjects, including healthy control subjects, subjects with mild cognitive impairment (MCI), and subjects with AD and other demenfias. 2) To obtain and make available for research, biomarker data on OADC subjects. This will include: a) apolipoprotein E (APOE) genotype on all subjects, b) single nucleotide polymorphism (SNP) profiles on select aging cohorts, and c) CSF Ap42, tau, BDNF, and F2-isoprostanes on select cohorts, d) plasma biomarker data on select cohorts. 3) To foster collaborative research involving genetics and other biomarkers emphasizing the research focus of the OADC. Research themes supported by the Core include 1) Identification of genetic predictors of both healthy brain aging and neurodegenerative dementia;2) Identification and validation of CSF and plasma biomarkers of neurodegeneration and mechanisms of neurodegeneration suitable for identification of high risk subjects, for identification of target mechanisms, and for use as outcome measures in clinical trials;3) Identification of CSF and plasma biomarkers of environmental predictors of both healthy brain aging and neurodegenerafive dementia. The Core maintains specimen banks and provides samples to qualified investigators with appropriate IRB approvals. Clinical and other data is also made available to invesfigators within HIPAA guidelines and according to local IRB regulations.

Public Health Relevance

The increasing emphasis on early intervention to prevent Alzheimer's disease in asymptomatic subjects will require that subjects and outcomes be characterized by a variety of biomarkers rather than relying on clinical outcomes alone. The understanding and utilization of these markers of risk and surrogate markers of disease will depend on the availability of the types of samples and data to be generated by this Core.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008017-25
Application #
8662582
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
25
Fiscal Year
2014
Total Cost
$203,975
Indirect Cost
$75,462
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Petersen, Johanna; Austin, Daniel; Kaye, Jeffrey A et al. (2014) Unobtrusive in-home detection of time spent out-of-home with applications to loneliness and physical activity. IEEE J Biomed Health Inform 18:1590-6
Wertheimer, Anne M; Bennett, Michael S; Park, Byung et al. (2014) Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol 192:2143-55
Kilgour, Alixe H M; Todd, Oliver M; Starr, John M (2014) A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse. BMC Geriatr 14:85
Shinto, Lynne; Quinn, Joseph; Montine, Thomas et al. (2014) A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis 38:111-20
Gray, Nora E; Morré, Jeff; Kelley, Jeremiah et al. (2014) Caffeoylquinic acids in Centella asiatica protect against amyloid-? toxicity. J Alzheimers Dis 40:359-73
Li, Ge; Millard, Steven P; Peskind, Elaine R et al. (2014) Cross-sectional and longitudinal relationships between cerebrospinal fluid biomarkers and cognitive function in people without cognitive impairment from across the adult life span. JAMA Neurol 71:742-51
Davis, Melinda M; Freeman, Michele; Kaye, Jeffrey et al. (2014) A systematic review of clinician and staff views on the acceptability of incorporating remote monitoring technology into primary care. Telemed J E Health 20:428-38
Thielke, Stephen M; Mattek, Nora C; Hayes, Tamara L et al. (2014) Associations between observed in-home behaviors and self-reported low mood in community-dwelling older adults. J Am Geriatr Soc 62:685-9
Peskind, Elaine R; Li, Ge; Shofer, Jane B et al. (2014) Influence of lifestyle modifications on age-related free radical injury to brain. JAMA Neurol 71:1150-4
Millard, Steven P; Lutz, Franziska; Li, Ge et al. (2014) Association of cerebrospinal fluid A*42 with A2M gene in cognitively normal subjects. Neurobiol Aging 35:357-64

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