The biomedical engineering and physics core facility is intended to make the following services available to the Division of Aging: 1) A mathematical modeling and computer simulation service is provided in order to analyze the dynamics of physiological systems and to reduce the use of vertebrate animal experimentation, when possible. 2) A physiological data acquisition service provides Holter monitoring equipment and a non-invasive, continuous blood pressure recording devise for monitoring human subjects. It also loans transducers, amplifiers, and recorders for the monitoring of physiological signals during animal experiments. 3) A physiological signal processing service digitizes, displays and analyzes physiological signals such as those obtained through service #2. Special software is provided for the analysis of ECG waveforms, blood pressure waveforms, and electrophysiological signals. General purpose software is provided for performing Fourier transforms, filtering and principal component analysis, as well as for calculating new non-linear diagnostics such as Lyapunov exponents. 4) An image acquisition service provides 2-D, M-mode and Doppler echocardiograms, specializing in difficult cases, which are common among elderly subjects. This service also makes available video cameras and recorders for the study of patient gait and movement, as well as a research grade fluorescence video microscope, a laser scanning microscope, and a tandem confocal scanning microscope for cell biology projects. 5) An image processing and interpretation service provides experienced readers of echocardiographic and nuclear medicine images. The service also performs digital image processing of images such as those recorded by the image acquisition service, including image enhancement and filtering, image segmentation and pattern recognition, and three-dimensional reconstruction from microscopic optical serial sections. 6) A biomechanics and biomotion service performs stress-strain measurements using a servo-hydraulic materials test system and provides an engineering analysis of gait and movement. 7) A prototype development service makes available to investigators a small machine shop and an electronics shop. It also provides prototype bladder prostheses and custom biomaterials.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008812-04
Application #
3768346
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
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Gangavati, Anupama; Hajjar, Ihab; Quach, Lien et al. (2011) Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc 59:383-9
Harrington, Mary Beth; Kraft, Malissa; Grande, Laura J et al. (2011) Independent association between preoperative cognitive status and discharge location after cardiac surgery. Am J Crit Care 20:129-37
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Rudolph, J L; Schreiber, K A; Culley, D J et al. (2010) Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review. Acta Anaesthesiol Scand 54:663-77
Rudolph, James L; Inouye, Sharon K; Jones, Richard N et al. (2010) Delirium: an independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc 58:643-9
Hajjar, Ihab; Sorond, Farzaneh; Hsu, Yi-Hsiang et al. (2010) Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study. Stroke 41:635-40
Newman, Lori R; Lown, Beth A; Jones, Richard N et al. (2009) Developing a peer assessment of lecturing instrument: lessons learned. Acad Med 84:1104-10
Rudolph, James L; Babikian, Viken L; Treanor, Patrick et al. (2009) Microemboli are not associated with delirium after coronary artery bypass graft surgery. Perfusion 24:409-15
Peng, C-K; Costa, Madalena; Goldberger, Ary L (2009) ADAPTIVE DATA ANALYSIS OF COMPLEX FLUCTUATIONS IN PHYSIOLOGIC TIME SERIES. Adv Adapt Data Anal 1:61-70

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