The BioImaging Resource Core (BRC) provides leadership, scientific expertise, and instrumental support in quantitative imaging, including MRI, CT, PET, DXA and ultrasound, critical to the WF OAIC's research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. The BRC is integrated with all OAIC cores and leads the development and implementation of imaging techniques and protocols to quantify and characterize body composition, especially skeletal (muscle and total, regional, and organ-specific adipose and fibrotic) tissue, and to obtain non-invasive measures of cardiovascular, nervous, vital organ, and musculoskeletal function. The Core also supports a robust image repository developed during the current cycle to facilitate cross-study comparisons and exploratory analyses of established imaging outcomes and rapid development and validation of new imaging phenotypes.
The Specific Aims of the BRC for the new cycle are to: 1) Support pilot, developmental, and externally- funded research projects with quantitative imaging phenotypes to be used as outcomes, mediators, effect modifiers, and exposures in both observational and intervention research focused on identifying and evaluating factors affecting pathways to physical disability; 2) Develop capabilities for assessment of new OAIC-relevant imaging measures, including exercise-related skeletal muscle perfusion and oxygenation; central nervous system measures of structure and function coupled with cerebrovascular assessments of microcirculatory reactivity, middle-size artery pulsatility and large vessel stiffness, and automated computer-derived measures of body composition and structure; and 3) Extend the application of advanced imaging techniques in support of the OAIC's programmatic goals by assisting early-career faculty members to integrate imaging into their work, collaborating with other OAIC Cores and investigators to develop multidisciplinary translational projects, and sharing with investigators beyond WF. In the initial year, the BRC will support 3 OAIC scholars, 3 pilot studies, 2 Research Development Projects, and 11 externally-funded projects. Dr. Greg Hundley will continue in his leadership role, to be joined by Dr. Christina Hugenschmidt. The BRC leadership team is composed of highly experienced, independently successful investigators with complementary skills and expertise with strong records of collaborative scientific and administrative achievements. They will ensure the achievement of the BRC goals and its contributions to the overall success of the WF OAIC.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
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Wake Forest University Health Sciences
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Bhasin, Shalender; Gill, Thomas M; Reuben, David B et al. (2018) Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. J Gerontol A Biol Sci Med Sci 73:1053-1061
Lucas, Alexander R; Klepin, Heidi D; Porges, Stephen W et al. (2018) Mindfulness-Based Movement: A Polyvagal Perspective. Integr Cancer Ther 17:5-15
Wasson, Emily; Rosso, Andrea L; Santanasto, Adam J et al. (2018) Neural correlates of perceived physical and mental fatigability in older adults: A pilot study. Exp Gerontol 115:139-147
Wilson, Quentin N; Wells, Magan; Davis, Ashley T et al. (2018) Greater Microbial Translocation and Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys. Sci Rep 8:11373
Kim, Sunghye; Miller, Michael E; Lin, Marina et al. (2018) Self- vs proxy-reported mobility using the mobility assessment tool-short form in elderly preoperative patients. Eur Rev Aging Phys Act 15:5
Anton, Stephen D; Moehl, Keelin; Donahoo, William T et al. (2018) Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring) 26:254-268
Datta, Rupak; Trentalange, Mark; Van Ness, Peter H et al. (2018) Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun 9:77-80
Justice, Jamie N; Ferrucci, Luigi; Newman, Anne B et al. (2018) A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience 40:419-436
Mokhtari, Fatemeh; Rejeski, W Jack; Zhu, Yingying et al. (2018) Dynamic fMRI networks predict success in a behavioral weight loss program among older adults. Neuroimage 173:421-433
Schoell, Samantha L; Beavers, Kristen M; Beavers, Daniel P et al. (2018) Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss. Aging Clin Exp Res :

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