The UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to promote research aimed at maintaining and restoring the independence of older persons. Through its theme of Translational Research to Maintain Independence, the UCLA OAlC's research extends across the full spectrum from T1 to T2 translational research. Within this theme, an important focus of the UCLA OAIC is on developing and understanding interventions that reduce inflammation. To accomplish its goals, the UCLA OAIC has established 4 Research Cores (Recruitment and Retention, Research Operations, Analysis and Cost Effectiveness, and Inflammatory Biology) and a new Information Dissemination Core that will facilitate OAlC-related research at every step (recruitment, measurement, data management, analysis, interpretation, and adoption of findings). Research cores provide support at 4 levels: Consultation (e.g., providing up to several hours of advice, reading a paper or a proposal) Short-term (e.g., up to a couple days of consultation, performing assays) Ongoing or long-term support (e.g., ongoing, part of the project team) Partnership on new proposals In addition, the UCLA OAIC Pilot and Exploratory Studies Core and Research Career Development Core stimulate new research via a pipeline of junior investigators and pilot awards and recruit successful investigators into OAlC-related research. A specific goal of the Center is to create teams of translational researchers and to train junior faculty in the principles of conducting research that bridges basic, clinical, and health services/dissemination research. The Leadership/Administrative Core ensures that these specific activities are accomplished and the goals of the UCLA OAIC are optimally achieved. By focusing efforts and resources through the OAIC, the timeline for research to develop, test, and disseminate promising innovations to maintain independence can be accelerated. At the end ofthe 5-year cycle, the UCLA OAIC will be a model program for translational research extending from basic science to clinical practice and policy and will have created a generation of new researchers who can begin to assume leadership in this theme.

Public Health Relevance

Preventing chronic diseases or reducing their effects requires research on the aging process, on diseases and disorders affecting older persons, on lifestyle modifications, on what treatments work best for whom, and on how best to deliver health care. By focusing efforts and resources through the UCLA OAIC, the timeline for research to develop, test, and disseminate promising innovations to maintain independence can be accelerated.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG028748-06
Application #
8179611
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Program Officer
Eldadah, Basil A
Project Start
2006-07-01
Project End
2013-06-30
Budget Start
2011-09-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$544,865
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Hernandez, Rosalba; Cheung, Elaine; Liao, Minli et al. (2017) The Association Between Depressive Symptoms and Cognitive Functioning in Older Hispanic/Latino Adults Enrolled in an Exercise Intervention. J Aging Health :898264317696776
Lee, A D; Spiegel, B M; Hays, R D et al. (2017) Gastrointestinal symptom severity in irritable bowel syndrome, inflammatory bowel disease and the general population. Neurogastroenterol Motil 29:
Lee, Yvonne C; Karlamangla, Arun S; Yu, Zhi et al. (2017) Pain Severity in Relation to the Final Menstrual Period in a Prospective Multiethnic Observational Cohort: Results From the Study of Women's Health Across the Nation. J Pain 18:178-187
Cho, Hyong Jin; Savitz, Jonathan; Dantzer, Robert et al. (2017) Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res 99:1-7
Lê-Scherban, Félice; Brenner, Allison B; Hicken, Margaret T et al. (2017) Child and adult socioeconomic status and the cortisol response to acute stress: Evidence from the Multi-Ethnic Study of Atherosclerosis. Psychosom Med :
Tsai, Kim M; Dahl, Ronald E; Irwin, Michael R et al. (2017) The Roles of Parental Support and Family Stress in Adolescent Sleep. Child Dev :
Chiang, Jessica J; Bower, Julienne E; Irwin, Michael R et al. (2017) Adiposity moderates links from early adversity and depressive symptoms to inflammatory reactivity to acute stress during late adolescence. Brain Behav Immun 66:146-155
Chiang, Jessica J; Kim, Joanna J; Almeida, David M et al. (2017) Sleep Efficiency Modulates Associations Between Family Stress and Adolescent Depressive Symptoms and Negative Affect. J Adolesc Health 61:501-507
Bates-Jensen, Barbara M; McCreath, Heather E; Patlan, Anabel (2017) Subepidermal moisture detection of pressure induced tissue damage on the trunk: The pressure ulcer detection study outcomes. Wound Repair Regen 25:502-511
Lake, Jordan E; Popov, Mikhail; Post, Wendy S et al. (2017) Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol 23:385-393

Showing the most recent 10 out of 365 publications