This application for an Einstein Nathan Shock Center (E-NSC) of excellence in the basic biology of aging is a natural step for enhancement of ongoing research, to strengthen the broad continuum of science and to address these biology of aging issues in its relation to human health. We have assembled a cohort of 48 Einstein investigators, 13 Regional members and 4 national members involved in ongoing research in Biology of Aging.
The aims of the NSC are:1) To enhance and expand the ongoing basic biology of aging enterprise at the Einstein Institute for Aging Research, we will establish 3 Research Resource Cores that are unique (do not exist in other NSCs) and novel (in their use of technology): a) Cellular and Tissue Aging Core (Cuervo), will provide measurements of cellular homeostasis as well as molecular modifications of protein, lipid, nucleic acids, and organelles;b) Healthy Aging Physiology Core (Barzilai), will perform sophisticated integrative metabolic studies in rodents to determine 'healthy aging'physiology such as in vivo whole body and organ- specific metabolism, body composition and energy balance, exercise, cardiac and cognitive/functional physiology analyses;and, c) Genomics and Epigenomics of Aging Core (Vijg), will provide investigators with whole genome association data from human centenarians and controls to assess their gene of interest in relationship to human aging and diseases as well as sequence enrichment for next generation re-sequencing of candidate gene regions, and genome-wide ONA methylation analysis using advanced high throughput technology. 2) To facilitate the planning and coordination of aging biology research activities at Einstein and other regional research institutions, and program enhancement through a lecture series and a yearly retreat (Administrative Core). 3) To provide support and a suitable environment for new investigators including pilot &feasibility awards, a designated-mentor system, and co-direction of a graduate course in Biology of Aging. 4) To develop potential regional and/or national resource Centers, by reaching out to regional investigators, and extending Core usage benefits to members of other NSCs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG038072-04
Application #
8511417
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M1))
Program Officer
Sierra, Felipe
Project Start
2010-08-15
Project End
2015-06-30
Budget Start
2013-08-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$519,143
Indirect Cost
$246,085
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Valdor, Rut; Mocholi, Enric; Botbol, Yair et al. (2014) Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol 15:1046-54
Chang, Anne L S; Atzmon, Gil; Bergman, Aviv et al. (2014) Identification of genes promoting skin youthfulness by genome-wide association study. J Invest Dermatol 134:651-7
Xiong, Xing-dong; Cho, Miook; Cai, Xiu-ping et al. (2014) A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. Mutat Res 761:15-20
Morimoto, Richard I; Cuervo, Ana Maria (2014) Proteostasis and the aging proteome in health and disease. J Gerontol A Biol Sci Med Sci 69 Suppl 1:S33-8
Milman, Sofiya; Atzmon, Gil; Huffman, Derek M et al. (2014) Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell 13:769-71
Scandiuzzi, Lisa; Ghosh, Kaya; Hofmeyer, Kimberly A et al. (2014) Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Rep 6:625-32
Lee, Changhan; Wan, Junxiang; Miyazaki, Brian et al. (2014) IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell 13:958-61
Carmi, Shai; Hui, Ken Y; Kochav, Ethan et al. (2014) Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nat Commun 5:4835
Bejarano, Eloy; Yuste, Andrea; Patel, Bindi et al. (2014) Connexins modulate autophagosome biogenesis. Nat Cell Biol 16:401-14
Schneider, Jaime L; Cuervo, Ana Maria (2014) Autophagy and human disease: emerging themes. Curr Opin Genet Dev 26:16-23

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