The Research Development Core of the Einstein- Nathan Shock Center (E-NSC) has leveraged resources to allow funding of 18 pilot and 3 feasibility (P&F) studies and 3 awards for development of Core technologies. Of these, 5 P&F studies led to NIH funding and 5 have pending funding (some with outstanding scores); in addition, 11 publications, resulted from studies funded before 2013. These P&F studies are designed to and will continue to enhance and support E-NSC science at Einstein and at the Brown University `mini-NSC'. We have expanded the Core to identify new faculty who have potential for `conversion' to aging research and provide continuous mentoring through grant applications and to assist junior faculty and investigators new to aging research. We also provide formal education in the biology of aging to recipients of P&F funding and anyone who wants to benefit from part or all of the formal graduate course. We believe that activities of this Core strengthen the E-NSC community, attract new investigators to aging-related research, and successfully promote new research endeavors in aging-related areas. Aging research is a key component of the Einstein scientific community, as shown by the Institution's commitment to provide up to $150,000 annually in matching funds for pilot grants. This will permit the funding of up to 3 to 5 P&F projects and 3 mini-P&Fs in any given year and provide smaller amounts to investigators in this next grant period for Research Resource Core use to obtain preliminary data before formal P&F application.
The Research Development Core of the Einstein Nathan Shock Center is crucial for recruitment and `conversion' of junior or senior investigators to the field of aging research. The Core will provide pilot and feasibility funding, provide mentoring and help investigators with development of grant proposals. Indeed we exemplified our success in the previous grant period, and have ensured institutional support. This Core is crucial in ensuring that we transform the E-NSC to a national/international resource to facilitate the ultimate goal of delaying human aging.
|Ayers, Emmeline; Shapiro, Miriam; Holtzer, Roee et al. (2017) Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults. J Clin Psychiatry 78:e529-e536|
|Gomes, Luciana R; Menck, Carlos F M; Cuervo, Ana Maria (2017) Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy 13:928-940|
|Manning, Alisa (see original citation for additional authors) (2017) A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes 66:2019-2032|
|Sathyan, Sanish; Barzilai, Nir; Atzmon, Gil et al. (2017) Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population. Neurobiol Aging 58:238.e1-238.e8|
|Tabrizian, Tahmineh; Wang, Donghai; Guan, Fangxia et al. (2017) Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. Endocr Relat Cancer 24:253-265|
|Ayers, Emmeline; Barzilai, Nir; Crandall, Jill P et al. (2017) Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging. J Gerontol A Biol Sci Med Sci 72:1649-1655|
|Maus, Mate; Cuk, Mario; Patel, Bindi et al. (2017) Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. Cell Metab 25:698-712|
|Dong, Xiao; Zhang, Lei; Milholland, Brandon et al. (2017) Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nat Methods 14:491-493|
|Vijg, Jan; Dong, Xiao; Zhang, Lei (2017) A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden. Exp Biol Med (Maywood) 242:1318-1324|
|Chusyd, Daniella E; Wang, Donghai; Huffman, Derek M et al. (2016) Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots. Front Nutr 3:10|
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