Gating of Protein Channels in Lipid Bilayer Membranes

Finkelstein, Alan

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 4R37GM029210-23
• Application #: 2832555
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Shapiro, Bert I
• Project Start: 1981-01-01
• Project End: 2004-12-31
• Budget Start: 2000-01-01
• Budget End: 2000-12-31
• Support Year: 23
• Fiscal Year: 2000
• Total Cost: $684,458

Institution

• Name: Albert Einstein College of Medicine
• Department: Physiology
• Type: Schools of Medicine
• DUNS #: 009095365
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Schiffmiller, Aviva; Anderson, Damon; Finkelstein, Alan (2015) Ion selectivity of the anthrax toxin channel and its effect on protein translocation. J Gen Physiol 146:183-92

Schiffmiller, Aviva; Finkelstein, Alan (2015) Ion conductance of the stem of the anthrax toxin channel during lethal factor translocation. J Mol Biol 427:1211-23

Kienker, Paul K; Wu, Zhengyan; Finkelstein, Alan (2015) Mapping the membrane topography of the TH6-TH7 segment of the diphtheria toxin T-domain channel. J Gen Physiol 145:107-25

Udho, Eshwar; Jakes, Karen S; Finkelstein, Alan (2012) TonB-dependent transporter FhuA in planar lipid bilayers: partial exit of its plug from the barrel. Biochemistry 51:6753-9

Basilio, Daniel; Kienker, Paul K; Briggs, Stephen W et al. (2011) A kinetic analysis of protein transport through the anthrax toxin channel. J Gen Physiol 137:521-31

Rodnin, Mykola V; Kyrychenko, Alexander; Kienker, Paul et al. (2011) Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J 101:L41-3

Basilio, Daniel; Jennings-Antipov, Laura D; Jakes, Karen S et al. (2011) Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins. J Gen Physiol 137:343-56

Jakes, Karen S; Finkelstein, Alan (2010) The colicin Ia receptor, Cir, is also the translocator for colicin Ia. Mol Microbiol 75:567-78

Rodnin, Mykola V; Kyrychenko, Alexander; Kienker, Paul et al. (2010) Conformational switching of the diphtheria toxin T domain. J Mol Biol 402:1-7

Janowiak, Blythe E; Finkelstein, Alan; Collier, R John (2009) An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci 18:348-58