During the past 20 years, studies on HIV and AIDS pathogenesis conducted at UCLA have relied on a wellrun, state-of-the-art virology core facility. The overall purpose of this facility has been to serve as an accessible resource for development of research techniques for UCLA investigators pursuing basic science, clinical science and behavioral science research in the field of HIV/AIDS. Throughout its existence the goals of the Virology Core have reflected the scientific needs of its users. Uniquely suited to the UCLA community, the Virology Core provides resources that are not easily obtainable commercially nor does it replace existing resources normally supported by individual research grants. To insure that the Virology/BSL3 Tissue Culture Core will continue to be an integral component of the UCLA CFAR/AIDS Institute, the following specific aims are proposed: 1. 1. To supply a readily available resource for UCLA investigators requiring virological support in the form of assays, technical expertise and storage/maintenance of viral specimen inventories for investigators; 2. To provide access and appropriate training for use of the Core-maintained biosafety level 3 (BSL3) tissue culture facility; 3. To serve as a """"""""wet lab"""""""" resource for behavioral and social science HIV investigators, offering access to routine bioassays and virological assessments. 4. To develop, evaluate and incorporate new procedures and assays relevant to the needs of UCLA HIV/AIDS investigators; 5. To foster collaboration among UCLA HIV/AIDS investigators, encourage the development of junior investigators and solicit the participation of established investigators not currently working in HIV/AIDS. 6. To offer training and expertise for international investigators and their laboratories who are pursuing collaborative ventures with UCLA faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028697-22
Application #
8230852
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
22
Fiscal Year
2011
Total Cost
$182,574
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Qi, Hangfei; Chu, Virginia; Wu, Nicholas C et al. (2017) Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A 114:2018-2023
Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia et al. (2017) Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol 13:914
Castaneda, Julie T; Harui, Airi; Roth, Michael D (2017) Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. J Neuroimmune Pharmacol 12:544-554
Harawa, Nina T; Holloway, Ian W; Leibowitz, Arleen et al. (2017) Serious concerns regarding a meta-analysis of preexposure prophylaxis use and STI acquisition. AIDS 31:739-740
Richardson-Harman, Nicola; Parody, Robert; Anton, Peter et al. (2017) Analytical Advances in the Ex Vivo Challenge Efficacy Assay. AIDS Res Hum Retroviruses 33:395-403
Foo, Suan-Sin; Chen, Weiqiang; Chan, Yen et al. (2017) Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy. Nat Microbiol 2:1558-1570
Bergstrom, K; Fu, J; Johansson, M E V et al. (2017) Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol 10:91-103
Farmer, Shu; Mindry, Deborah; Comulada, W Scott et al. (2017) Mobile Phone Ecological Momentary Assessment of Daily Stressors Among People Living With HIV: Elucidating Factors Underlying Health-Related Challenges in Daily Routines. J Assoc Nurses AIDS Care 28:737-751
Tan, Diane; Holloway, Ian W; Gildner, Jennifer et al. (2017) Alcohol Use and HIV Risk Within Social Networks of MSM Sex Workers in the Dominican Republic. AIDS Behav 21:216-227
Bristow, Claire C; Lee, Sung-Jae; Severe, Linda et al. (2017) Attributes of diagnostic tests to increase uptake of dual testing for syphilis and HIV in Port-au-Prince, Haiti. Int J STD AIDS 28:259-264

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