This renewal extends our work during the last award period and seeks to translate these findings to the criminal justice system. Our accomplishments include: (a) developing methods for processing transdermal alcohol concentration data that yield clinically-meaningful quantification of drinking; (b) demonstrating contingency management can be successfully implemented using transdermal alcohol monitors and that contingency management can produce sustained reductions in heavy drinking in non-treatment-seeking problematic drinkers; and (c) establishing collaborations within the judicial system. Specifically, we propose to implement this contingency management program as an adjunctive intervention for driving while intoxicated (DWI) offenders who are mandated to transdermal alcohol monitoring and the majority of whom continue to misuse alcohol despite court prohibition while awaiting trial (pretrial period). Contingency Management and Control groups will experience 8-weeks of intervention (or sham) and 12-months follow-up for alcohol use. During the course of the study, we will examine how constructs from the Theory of Planned Behavior relate to observed drinking outcomes. Our primary aims are: to determine whether contingency management reduces drinking among DWI offenders court-ordered to undergo transdermal alcohol monitoring; to evaluate the extent to which reductions in drinking among DWI offenders assigned to the Contingency Management group are sustained during follow-up; how outcomes relate to constructs identified in the Theory of Planned Behavior (Attitudes, Social Norms, Behavioral Control and Intentions); and determine the costs, benefits, and net benefits of this program on the criminal justice system. The results of this study will inform the eventual integration of contingency management into traditional judicial approaches. Lastly, exploratory analyses will: (a) examine how study participation relates to outcomes tracked by the criminal justice system; and (b) test for impact of psychiatric or other substance use comorbidity; and (c) characterize the impact of alcohol use on participants' lives.

Public Health Relevance

Public Health Significance: Driving while intoxicated offenders, largely ignored by the research community, pose a significant risk to themselves and society. The results of this study will inform the development of interventions aimed at this unique population of risky drinkers. The proposed study will also provide fundamental information on how specific behavioral processes relate to individual differences in the ability to reduce alcohol consumption and inform us about how differences in these behavioral processes might be leveraged to affect better and more cost-effective outcomes within the criminal justice system.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA014988-12A1
Application #
9234686
Study Section
Interventions to Prevent and Treat Addictions Study Section (IPTA)
Program Officer
Bloss, Gregory
Project Start
2005-04-01
Project End
2022-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
12
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Texas Health Science Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Lopez-Cruzan, Marisa; Roache, John D; Hill-Kapturczak, Nathalie et al. (2018) Pharmacokinetics of Phosphatidylethanol 16:0/20:4 in Human Blood After Alcohol Intake. Alcohol Clin Exp Res 42:2094-2099
Mathias, Charles W; Hill-Kapturczak, Nathalie; Karns-Wright, Tara E et al. (2018) Translating transdermal alcohol monitoring procedures for contingency management among adults recently arrested for DWI. Addict Behav 83:56-63
Hill-Kapturczak, Nathalie; Dougherty, Donald M; Roache, John D et al. (2018) Differences in the Synthesis and Elimination of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 After Acute Doses of Alcohol. Alcohol Clin Exp Res 42:851-860
Karns-Wright, Tara E; Roache, John D; Hill-Kapturczak, Nathalie et al. (2017) Time Delays in Transdermal Alcohol Concentrations Relative to Breath Alcohol Concentrations. Alcohol Alcohol 52:35-41
Mullen, Jillian; Mathias, Charles W; Karns, Tara E et al. (2016) Behavioral Impulsivity Does Not Predict Naturalistic Alcohol Consumption or Treatment Outcomes. Addict Disord Their Treat 15:120-128
Badawy, Abdulla A-B; Dougherty, Donald M (2016) Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion. Int J Tryptophan Res 9:31-49
Dougherty, Donald M; Hill-Kapturczak, Nathalie; Liang, Yuanyuan et al. (2015) The Potential Clinical Utility of Transdermal Alcohol Monitoring Data to Estimate the Number of Alcoholic Drinks Consumed. Addict Disord Their Treat 14:124-130
Hill-Kapturczak, Nathalie; Roache, John D; Liang, Yuanyuan et al. (2015) Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring. Psychopharmacology (Berl) 232:115-23
(2015) Corrigendum to “Transdermal alcohol concentration data collected during a contingency management program to reduce at-risk drinking” Drug Alcohol Depend 149:304
Dougherty, Donald M; Lake, Sarah L; Hill-Kapturczak, Nathalie et al. (2015) Using contingency management procedures to reduce at-risk drinking in heavy drinkers. Alcohol Clin Exp Res 39:743-51

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