This is a proposed K24 Mid-Career Investigator Award in Patient-Orient Research (POR) for Dr. Peter Wayne, Director of Research at Osher Center for Integrative Medicine (jointly based at Harvard Medical School (HMS) and Brigham and Women's Hospital (BWH)), and Assistant Professor in Medicine at HMS (promotion to Associate Professor pending). Over the past 15 years, Dr. Wayne has built a successful, continuously funded, program of research focused on evaluating the clinical impact of multiple integrative medicine (IM) therapies, including Tai Chi, acupuncture, and manual therapies, for the prevention and rehabilitation of a broad range of chronic health conditions. Drawing on multiple experimental and analytic skills from an earlier research career in evolutionary biology, and significant clinical experience as a practitioner and teacher of integrative therapies, he has developed the knowledge and skills necessary to conduct high quality POR and to guide others in this process. The coordinated set of initiatives proposed in this K24 award will provide Dr. Wayne with needed protected time to significantly: 1) expand the quantity and quality of his mentoring of junior investigators committed to IM research; and 2) increase his research skills and expand his portfolio of research as a foundation for leading future innovative and high impact studies informing the use of IM therapies and models. Initiatives to enhance his mentoring include: Participation in the BWH faculty leadership training program; development of a more structured and comprehensive mentoring plan that is tailored to the individual level of the trainees; regular meetings with an assembled team of committed senior faculty advisors; and reduction in time devoted to administrative activities which will be reallocated to mentoring. The success of these initiatives will be augmented by Dr. Wayne's current leadership role at the Osher Center; access to a rich pool of mentee candidates via two long-standing NIH-funded T32 Fellowships for which he serves as faculty, as well as multiple other local, national, and international training and research programs with which the Osher Center collaborates; and the rich educational resources afforded across HMS hospitals and institutions, including the Harvard Catalyst, an NIH-funded Clinical and Translational Science Award site. Dr. Wayne's current research program is highly collaborative, and includes two NIH R01s for which he serves as a multiple PI, two additional foundation-funded studies that he leads as PI, and 6 other studies for which he serves as a key collaborator. These studies, along with future studies to be developed, are summarized in a Research Strategy centered around three global aims: 1) to evaluate integrative medical approaches to chronic low back pain; 2) to conduct translational research evaluating the effectiveness and cost-effectiveness of Tai Chi for rehabilitation and prevention of chronic disease related functional decline; 3) to evaluate the impact of Tai Chi on cognitive and motor processes in Parkinson's disease. Collectively, current and future planned studies would provide a diverse, creative, well-funded, and supportive research environment to train junior IM investigators.

Public Health Relevance

While promising integrative medicine (IM) therapies, including mind-body practices, are increasingly being utilized by all segments of our society, limited research evidence makes their role in the future of our rapidly changing health care system unclear. This K24 award will provide the candidate with needed protected time to significantly expand the quantity and quality of his mentoring of junior investigators committed to IM research and increase his research skills and expand his portfolio of research as a foundation for leading future innovative and high impact studies informing the use of IM therapies and models.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Mudd, Lanay Marie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Wayne, Peter M; Eisenberg, David M; Osypiuk, Kamila et al. (2018) A Multidisciplinary Integrative Medicine Team in the Treatment of Chronic Low-Back Pain: An Observational Comparative Effectiveness Study. J Altern Complement Med 24:781-791
Tick, Heather; Nielsen, Arya; Pelletier, Kenneth R et al. (2018) Evidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care: The Consortium Pain Task Force White Paper. Explore (NY) 14:177-211
Wayne, Peter M; Lee, M S; Novakowski, J et al. (2018) Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J Cancer Surviv 12:256-267
Lo, On-Yee; Conboy, Lisa A; Rukhadze, Alexandra et al. (2018) In the Eyes of Those Who Were Randomized: Perceptions of Disadvantaged Older Adults in a Tai Chi Trial. Gerontologist :
Langevin, Helene M; Wayne, Peter M (2018) What Is the Point? The Problem with Acupuncture Research That No One Wants to Talk About. J Altern Complement Med 24:200-207
Vergara-Diaz, Gloria; Osypiuk, Kamila; Hausdorff, Jeffrey M et al. (2018) Tai Chi for Reducing Dual-task Gait Variability, a Potential Mediator of Fall Risk in Parkinson's Disease: A Pilot Randomized Controlled Trial. Glob Adv Health Med 7:2164956118775385
Osypiuk, Kamila; Thompson, Evan; Wayne, Peter M (2018) Can Tai Chi and Qigong Postures Shape Our Mood? Toward an Embodied Cognition Framework for Mind-Body Research. Front Hum Neurosci 12:174
You, Tongjian; Ogawa, Elisa F; Thapa, Saurja et al. (2018) Tai Chi for older adults with chronic multisite pain: a randomized controlled pilot study. Aging Clin Exp Res 30:1335-1343
Wayne, Peter M; Gagnon, Margaret M; Macklin, Eric A et al. (2017) The Mind Body-Wellness in Supportive Housing (Mi-WiSH) study: Design and rationale of a cluster randomized controlled trial of Tai Chi in senior housing. Contemp Clin Trials 60:96-104
Carlson, Linda E; Zelinski, Erin L; Speca, Michael et al. (2017) Protocol for the MATCH study (Mindfulness and Tai Chi for cancer health): A preference-based multi-site randomized comparative effectiveness trial (CET) of Mindfulness-Based Cancer Recovery (MBCR) vs. Tai Chi/Qigong (TCQ) for cancer survivors. Contemp Clin Trials 59:64-76

Showing the most recent 10 out of 13 publications