The longstanding research relationship between CWRU, primarily represented by the Case CFAR and the Case TBRU, the government of Uganda and Makerere University, has resulted in the development of an extensive research infrastructure in Uganda. CWRU was one of the first US academic institutions to move from "safari" science to a strong integrated research approach involving teaching, training, and employment. We recently celebrated our twenty-year collaboration with the Ugandan government and Makerere University. Currently over 200 Ugandan scientists and health care professionals are actively involved in our collaborative programs. A major limitation to new initiatives in the developing world has been the lack of state-of-the-art laboratory facilities on site. The Case CFAR has fostered seminal studies on TB and HIV/AIDS by providing a state-of-the-art laboratories and facilities for clinical virology and molecular biology in Uganda. All the research laboratories (Virology/Molecular Biology, Immunology, Mycobacterial, and STD laboratories) are directed on site by Ugandans, all of whom have received advanced degrees from CWRU through the Fogarty AIDS Training Program. To further facilitate sharing of resources and to promote/support new research initiatives, all laboratory facilities and services associated with HIV/AIDS research are being administered by the Case CFAR Uganda Laboratory Core with the following two main Specific Aims: To provide comprehensive laboratory services to facilitate HIV/AIDS-related research projects of CFAR investigators To provide a mechanism for training of Ugandan scientists in collaboration with CWRU and Fogarty AIDS Training Grant.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
United States
Zip Code
Longenecker, Chris T; Jiang, Ying; Orringer, Carl E et al. (2014) Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection. AIDS 28:969-77
Mbonye, Uri; Karn, Jonathan (2014) Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology 454-455:328-39
Gibson, Richard M; Meyer, Ashley M; Winner, Dane et al. (2014) Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism. Antimicrob Agents Chemother 58:2167-85
Chiu, Yen-Ling; Shan, Liang; Huang, Hailiang et al. (2014) Sprouty-2 regulates HIV-specific T cell polyfunctionality. J Clin Invest 124:198-208
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2014) Oral mycobiome analysis of HIV-infected patients: identification of Pichia as an antagonist of opportunistic fungi. PLoS Pathog 10:e1003996
Chandra, Jyotsna; Pearlman, Eric; Ghannoum, Mahmoud A (2014) Animal models to investigate fungal biofilm formation. Methods Mol Biol 1147:141-57
Olvera-GarcĂ­a, Gustavo; Espinosa, Enrique; Sieg, Scott F et al. (2014) Cytomegalovirus-specific responses of CD38? memory T cells are skewed towards IFN-? and dissociated from CD154 in HIV-1 infection. AIDS 28:311-6
Tabler, Caroline O; Lucera, Mark B; Haqqani, Aiman A et al. (2014) CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. J Virol 88:4976-86
Zapanta Rinonos, Serendipity; Rai, Urvashi; Vereb, Sydney et al. (2014) Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae. Eukaryot Cell 13:1393-402
Hulgan, Todd; Boger, M Sean; Liao, Diana H et al. (2014) Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. Mediators Inflamm 2014:803095

Showing the most recent 10 out of 320 publications