The International Core is designed specifically to support the international research base of UNC, FHl, and RTI, including collaborating in-country investigators, foster synergy across the Cores and CFARs, and enhance HIV/AIDS research collaborations in key countries: Malawi, South Africa, the Democratic Republic of Congo (DRC), China, Russia, and in Central America, Nicaragua and Guatemala. The sheer volume and density of HIV in our collaborating sites allows research questions to be addressed with speed and efficiency impossible in places with lower HIV prevalence. A substantial part ofthe UNC CFAR's NIH support for HIV research comes for work undertaken outside the United States. This has involved leadership roles in the nternational NIH networks, including HPTN, the International ACTG, the CHAVI (Center for HIV Vaccine Immunology), Microbicide Trials Network and IMPAACT. UNC's global AIDS programs have led to the formation of an NIH HIV Clinical Trials Unit (CTU) in Lilongwe, Malawi, widely viewed as one ofthe best and most productive in the NIH Networks. Investigator-initiated research on HIV clinical care and biological and social factors related to HIV transmission and prevention of transmission is ongoing in Malawi, South Africa, China, the DRC, and Russia;research devoted to STD and HIV overlap has been a focus in China. UNC investigators have participated in virtually all Fogarty research Training Programs including AITRP, the Fogarty Center for Bioethics in Francophone Africa, the ICORTA-TB/AIDS, and the Fogarty Ellison pre- and post-doctoral programs. The Core provides: support for basic, clinical, and behavioral/social science infrastructure and capacity building;training in-country and at UNC in protocol development, IRB, and regulatory;and consideration of a range of ethical challenges raised by international research collaborations. The Core has provided leadership in facilitating cross-Core collaborations, mentoring junior investigators, manuscript and grant preparation for international collaborators, and communicating results from international research.

Public Health Relevance

The International Core will impact public health in several ways. By investing in laboratory infrastructure, clinical and social/behavioral research capacity, development of clinical databases and specimen repositories, and mentored training needed to sustain these investments, the Core has facilitated important scientific and clinical discoveries that have been translated into improved medical treatment for people most affected by the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-16
Application #
8531846
Study Section
Special Emphasis Panel (ZAI1-ELB-A)
Project Start
2013-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
16
Fiscal Year
2013
Total Cost
$126,326
Indirect Cost
$35,105
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
White, Becky L; Walsh, Joan; Rayasam, Swati et al. (2015) What Makes Me Screen for HIV? Perceived Barriers and Facilitators to Conducting Recommended Routine HIV Testing among Primary Care Physicians in the Southeastern United States. J Int Assoc Provid AIDS Care 14:127-35
Jennings, Larissa; Rompalo, Anne M; Wang, Jing et al. (2015) Prevalence and correlates of knowledge of male partner HIV testing and serostatus among African-American women living in high poverty, high HIV prevalence communities (HPTN 064). AIDS Behav 19:291-301
Rosen, David L; Golin, Carol E; Grodensky, Catherine A et al. (2015) Opt-out HIV testing in prison: informed and voluntary? AIDS Care 27:545-54
Evon, Donna M; Golin, Carol E; Bonner, Jason E et al. (2015) Adherence during antiviral treatment regimens for chronic hepatitis C: a qualitative study of patient-reported facilitators and barriers. J Clin Gastroenterol 49:e41-50
Joseph, Sarah B; Arrildt, Kathryn T; Sturdevant, Christa B et al. (2015) HIV-1 target cells in the CNS. J Neurovirol 21:276-89
Edwards, Jessie K; Cole, Stephen R; Adimora, Adaora et al. (2015) Illustration of a measure to combine viral suppression and viral rebound in studies of HIV therapy. J Acquir Immune Defic Syndr 68:241-4
Onsomu, Elijah O; Abuya, Benta A; Okech, Irene N et al. (2015) Association between domestic violence and HIV serostatus among married and formerly married women in Kenya. Health Care Women Int 36:205-28
O'Shea, Michele S; Rosenberg, Nora E; Hosseinipour, Mina C et al. (2015) Effect of HIV status on fertility desire and knowledge of long-acting reversible contraception of postpartum Malawian women. AIDS Care 27:489-98
Cole, Stephen R; Lau, Bryan; Eron, Joseph J et al. (2015) Estimation of the standardized risk difference and ratio in a competing risks framework: application to injection drug use and progression to AIDS after initiation of antiretroviral therapy. Am J Epidemiol 181:238-45
Rahangdale, Lisa; De Paris, Kristina; Kashuba, Angela D M et al. (2015) Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr 68:420-4

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